复方苓榆洗剂治疗婴幼儿湿疹湿热浸淫型60例临床观察  

Clinical observation on 60 cases of infantile eczema with dampness-heat intrusion and spreading type treated by Fufang Lingyu Xiji(复方苓榆洗剂)

作　　者：郭凯[1] 黄长婷 肖和印[1] 陈艳霞[1] 毛娜[1] 杨兵宾[1] 张丽[1] 王红娟[1] GUO Kai;HUANG Changting;XIAO Heyin;CHEN Yanxia;MAO Na;YANG Bingbin;ZHANG Li;WANG Hongjuan(Department of Pediatrics,Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing,100102,China)

机构地区：[1]中国中医科学院望京医院儿科,北京100102

出　　处：《中医儿科杂志》2022年第5期42-47,共6页Journal of Pediatrics of Traditional Chinese Medicine

基　　金：首都临床特色应用研究与成果推广项目(Z161100000516112)。

摘　　要：目的 观察复方苓榆洗剂治疗婴幼儿湿疹湿热浸淫型的临床疗效。方法 选取2016年9月至2019年4月中国中医科学院望京医院儿科门诊就诊的120例湿疹湿热浸淫型患儿,按就诊顺序随机分为治疗组和对照组,各60例。对照组予冰黄肤乐软膏均匀涂擦患处,治疗组予复方苓榆洗剂涂擦患处,均每日3次。2组均连续治疗14 d后统计临床疗效。结果 对照组总有效率为58.33%(35/60),治疗组为96.67%(58/60),2组总有效率比较,差异有统计学意义(P<0.05)。2组治疗前靶皮损程度(红斑、丘疹/丘疱疹/水疱、糜烂、渗出/结痂/鳞屑、全身皮损面积)、瘙痒程度积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组上述积分均显著下降,经统计学分析,差异有统计学意义(P<0.01),且治疗组下降更显著(P<0.05)。2组中医证候总积分组内、组间比较,差异均有统计学意义(P<0.01)。结论 复方苓榆洗剂治疗婴幼儿湿疹湿热浸淫型,不仅能显著改善患儿临床症状、体征,疗效显著,而且操作方便,无刺激性,患儿及其家长易于接受,依从性较好,因此值得临床推广应用。Objective To observe the clinical efficacy of Fufang Lingyu Xiji(复方苓榆洗剂,FFLYXJ)in the treatment of infantile eczema with dampness-heat intrusion and spreading type.Methods From September 2016 to April 2019,120 infantile eczema with dampness-heat intrusion and spreading type consulted in outpatient service of pediatrics department of Wangjing Hospital of China Academy of Chinese Medical Sciences were chosen and randomly divided into treatment group and control group by visit order,with 60 cases in each group.The control group was given even inunction of Binghuang Fule Ruangao(冰黄肤乐软膏)on the affected parts,whereas the treatment group was given inunction of FFLYXJ on the affected parts,3 times per day each.The clinical efficacy was assessed after the 2 groups were both continuously treated for 14 days.Results The total effective rate of the control group was 58.33%(35/60),that of the treatment group was 96.67%(58/60),and the difference was statistically significant by rank sum test(P<0.05).Before treatment,there were no statistically significant differences in the scores of target skin lesions(erythema,papule/papule-vesicle/blister,erosion,exudation/scab/scale,generalized skin lesion area)and pruritus intensity between the 2 groups(P>0.05),indicating comparability.After treatment,the scores of target skin lesions(erythema,papule/papule-vesicle/blister,erosion,exudation/scab/scale,generalized skin lesion area)and pruritus intensity significantly decreased,and the difference was statistically significant as compared with the same group before treatment(P<0.01),moreover,the decrease in the treatment group was more significant(P<0.05).There were statistically significant differences in the total score of TCM syndromes within and between the 2 groups(P<0.01).Conclusion FFLYXJ can not only markedly improve the clinical symptoms and signs of infantile eczema with dampness-heat intrusion and spreading type,but also has significant curative effects.It is easy to operate,non irritating,easy to accept by

关 键 词：婴幼儿湿疹 湿热浸淫型 复方苓榆洗剂 临床观察 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]