面向骨科植入物的仿生多孔结构设计与制造方法  

Design and Manufacture Method of Bionic Porous Structures for Orthopedic Implants

作　　者：焦晨 晁龙 朱磊 沈理达[1] 梁绘昕 戴宁[1] 王长江 孙骏[4] JIAO Chen;CHAO Long;ZHU Lei;SHEN Lida;LIANG Huixin;DAI Ning;WANG Changjiang;SUN Jun(College of Mechanical and Electronic Engineering,Nanjing University of Aeronautics and Astronautics,Nanjing,210016;Drum Tower Hospital Affiliated to Nanjing University Medical School,Nanjing,210008;University of Sussex,Brighton,United Kingdom,BN19RH;Adverse Drug Reaction Monitoring Center of Jiangsu Province,Nanjing,210002)

机构地区：[1]南京航空航天大学机电学院,南京210016 [2]南京大学医学院附属鼓楼医院,南京210008 [3]萨塞克斯大学,布莱顿,英国BN19RH [4]江苏省药品不良反应监测中心,南京210002

出　　处：《中国机械工程》2022年第23期2844-2850,共7页China Mechanical Engineering

基　　金：国家重点研发计划(2018YFB1105400,2018YFB1105801);江苏省科技厅重点研发计划(BE2019002)。

摘　　要：采用激光选区熔化及陶瓷光固化技术制备了具有多孔特征的金属骨支架与陶瓷骨支架,采用压缩试验评价了两种骨支架的力学性能,采用体外培养MC3T3-E1细胞的方式评估了骨支架的生物相容性。研究结果表明,支架不规则度和孔隙率的变化均会影响支架的力学性能与生物性能;金属支架具有更优良的力学性能,陶瓷支架具有更接近松质骨的力学性能;不规则孔隙有助于细胞附着,使骨支架具有更好的生物相容性。The selective laser melting and ceramic digital light processing methods were adopted to fabricate metal scaffolds and ceramic scaffolds with porous structures.The compression test was employed to evaluate the mechanics behaviors of the scaffolds.The in vitro cultivation of MC3T3E1 cells was used to evaluate the biocompatibility of the scaffolds.The test results show that the irregularity and porosity are influential to the mechanics properties and biocompatibility;metal scaffolds have better mechanics properties,while ceramic scaffoldsis are closer to the cancellous bones;the irregular pores show better performance of cell adhesion which improves the biocompatibility of the scaffolds.

关 键 词：支架 增材制造 多孔结构 力学性能 生物相容性 

分 类 号：TG665[金属学及工艺—金属切削加工及机床] TH164[机械工程—机械制造及自动化]