双氯芬酸钠盐酸利多卡因与曲马多注射液用于四肢急性创伤镇痛的临床效果比较  

Comparison of clinical effects of diclofenac sodium lidocaine hydrochloride and tramadol injection for acute trauma analgesia of extremities

作　　者：李静涵 黄蓉 LI Jinghan;HUANG Rong(The Third Affiliated Hospital of Chongqing Medical University(Gener Hospital),Chongqing 401120,China;不详)

机构地区：[1]重庆医科大学附属第三医院(捷尔医院),重庆市401120 [2]重庆市永川区中医院,402160

出　　处：《临床合理用药杂志》2022年第32期7-10,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的比较双氯芬酸钠盐酸利多卡因与曲马多注射液用于四肢急性创伤镇痛的临床效果。方法选取2020年4月—2021年4月重庆医科大学附属第三医院(捷尔医院)收治的四肢急性创伤患者50例,采用随机数字表法分为观察组和对照组,各25例。对照组予盐酸曲马多注射液一次性肌内注射,观察组予双氯芬酸钠盐酸利多卡因注射液一次性肌内注射。比较2组不同时点(治疗前与治疗15 min、30 min、2 h、4 h)的疼痛(VAS)评分,治疗前后舒适度(BCS)评分、生命体征[心率(HR)、平均动脉压(MAP)、收缩压(SBP)、舒张压(DBP)]变化及不良反应。结果治疗15 min、30 min、2 h、4 h时,2组VAS评分均较治疗前降低,且同时点观察组评分低于对照组(P<0.05或P<0.01);治疗后,2组BCS评分较治疗前上升,观察组HR、MAP、SBP、DBP均较治疗前下降,且观察组上述指标上升或下降的程度大于对照组(P<0.05或P<0.01);观察组不良反应总发生率为4.00%,低于对照组的24.00%(χ^(2)=4.153,P=0.042)。结论双氯芬酸钠盐酸利多卡因相较于曲马多注射液用于四肢急性创伤镇痛的临床效果更为显著,可明显缓解疼痛,提升患者舒适性,不良反应发生风险明显降低,患者各项生命体征改善明显,值得临床推广应用。Objective Comparison of the clinical effect of diclofenac sodium lidocaine hydrochloride and tramadol injection for acute trauma analgesia of extremities.Methods A total of 50 patients with acute limb trauma who were admitted to the Third Affiliated Hospital of Chongqing Medical University(Gener Hospital)from April 2020 to April 2021 were selected and divided into an observation group and a control group by random number table method,with 25 cases in each.The control group was given a one-time intramuscular injection of tramadol hydrochloride injection,and the observation group was given a one-time intramuscular injection of diclofenac sodium lidocaine hydrochloride injection.The pain(VAS)scores of the two groups at different time points(before treatment and at 15 min,30 min,2 h,4 h after treatment)were compared,the changes of comfort(BCS)score,vital signs[heart rate(HR),mean arterial pressure(MAP),systolic blood pressure(SBP),diastolic blood pressure(DBP)]and adverse reactions were compared between the two groups before and after treatment.Results At 15 min,30 min,2 h,and 4 h of treatment,the VAS scores in both groups were lower than those before treatment,and the scores in the observation group were lower than those in the control group at the same time(P<0.05 or P<0.01).After treatment,the BCS scores of the two groups increased compared with those before treatment,and HR,MAP,SBP,DBP in the observation group were all decreased compared with those before treatment,and the increase or decrease of the above indexes in the observation group was greater than that in the control group(P<0.05 or P<0.01).The total incidence of adverse reactions in the observation group was 4.00%,which was lower than 24.00%in the control group(χ^(2)=4.153,P=0.042).Conclusion Compared with tramadol injection,diclofenac sodium lidocaine hydrochloride has a more significant clinical effect on analgesia for acute trauma analgesia of extremities,which can significantly relieve pain,improve patient comfort,significantly reduce the risk of ad

关 键 词：四肢急性创伤 双氯芬酸钠盐酸利多卡因 曲马多注射液 镇痛效果 

分 类 号：R658[医药卫生—外科学]