曲美他嗪联合米力农治疗高血压性心脏病伴心力衰竭的临床疗效及安全性  

Clinical efficacy and safety of trimetazidine combined with milrinone in the treatment of hypertensive heart disease with heart failure

作　　者：赵海兰 陈清兰 ZHAO Hailan;CHEN Qinglan(Leping People′s Hospital,Jiangxi Province,Leping 333300,China)

机构地区：[1]江西省乐平市人民医院,333300

出　　处：《临床合理用药杂志》2022年第31期27-30,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察曲美他嗪联合米力农治疗高血压性心脏病伴心力衰竭的临床疗效及安全性。方法回顾性选择2018年1月—2020年12月在江西省乐平市人民医院接受治疗的高血压性心脏病伴心力衰竭患者50例,根据治疗方案的不同分成联合组和对照组各25例。在常规治疗基础上,对照组采用米力农治疗,联合组采用曲美他嗪联合米力农治疗。比较2组患者治疗效果、心电图表现复常时间、心功能指标复常时间、住院总时间,治疗前后C反应蛋白(CRP)、白细胞计数(WBC)、生活质量评分、心力衰竭相关指标及药物不良反应。结果联合组患者总有效率为92.00%,高于对照组的64.00%,差异有统计学意义(χ^(2)=5.711,P=0.017)。联合组患者的心电图表现复常时间、心功能指标复常时间及住院总时间均短于对照组,差异均有统计学意义(P<0.01)。治疗后,2组患者的CRP、WBC水平均低于治疗前,健康调查简表(SF-36)评分均高于治疗前,且联合组患者降低/升高幅度均大于对照组,差异均有统计学意义(P<0.01);2组患者的脑钠肽(BNP)、N末端脑钠肽前体(NT-proBNP)、左室收缩末期内径(LVESD)及左室舒张末期内径(LVEDD)均低于治疗前,左室射血分数(LVEF)均高于治疗前,且联合组患者降低/升高幅度均大于对照组,差异均有统计学意义(P<0.01)。联合组患者不良反应总发生率为4.00%,低于对照组的28.00%,差异有统计学意义(χ^(2)=5.357,P=0.021)。结论曲美他嗪联合米力农治疗高血压性心脏病伴心力衰竭可有效提高疗效,缩短心电图表现复常时间、心功能指标复常时间、住院总时间,改善炎性因子指标、心率变异性指标、生活质量、心功能指标,减少药物不良反应。Objective To observe the clinical efficacy and safety of trimetazidine combined with milrinone in the treatment of hypertensive heart disease with heart failure.Methods Fifty patients with hypertensive heart disease and heart failure who were treated in Leping People′s Hospital of Jiangxi Province from January 2018 to December 2020 were retrospectively selected,according to the different treatment plans,they were divided into combined group and control group with 25 cases in each.On the basis of conventional treatment,the control group was treated with milrinone,and the combination group was treated with trimetazidine combined with milrinone.The treatment effect,time to normalization of electrocardiogram,time to normalization of cardiac function indexes,total hospitalization time,C-reactive protein(CRP),white blood cell count(WBC),quality of life score,heart failure-related indexes before and after treatment and adverse drug effects were compared between the two groups.Results The total effective rate was 92.00%in the combined group,which was higher than 64.00%in the control group,and the difference was statistically significant(χ^(2)=5.711,P=0.017).The time to normalization of electrocardiogram manifestations,the time to normalization of cardiac function indexes and the total hospitalization time of the patients in the combined group were all shorter than those in the control group,and the differences were statistically significant(P<0.01).After treatment,the levels of CRP and WBC in the two groups were lower than those before treatment,and the scores of short form of health survey(SF-36)were higher than those before treatment,and the decrease/increase range of patients in the combined group were greater than those in the control group,and the differences were statistically significant(P<0.01);The brain natriuretic peptide(BNP),N-terminal pro-brain natriuretic peptide(NT-proBNP),left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)in the two groups were all lower than

关 键 词：高血压性心脏病 心力衰竭 曲美他嗪 米力农 生活质量 

分 类 号：R541.6[医药卫生—心血管疾病] R541.3[医药卫生—内科学]