血小板衍生生长因子、Beclin1与血液透析患者血管钙化的关系  

Correlations of platelet-derived growth factor and Beclin1 with vascular calcification in hemodialysis patients

作　　者：生玉平 马晓迎[1] 孙福云[1] 杨星梦 王娜[1] 张浩然[1] 徐海平[1] SHENG Yuping;MA Xiaoying;SUN Fuyun;YANG Xingmeng;WANG Na;ZHANG Haoran;XU Haiping(the Second Nephrology Department,Cangzhou Central Hospital of Hebei Province,Cangzhou,Hebei,061000)

机构地区：[1]河北省沧州市中心医院肾内二科,河北沧州061000

出　　处：《实用临床医药杂志》2022年第21期60-64,共5页Journal of Clinical Medicine in Practice

基　　金：河北省沧州市重点研发计划指导项目(204106081)。

摘　　要：目的探讨血清血小板衍生生长因子-BB(PDGF-BB)、自噬相关分子Beclin1水平与行维持性血液透析(MHD)患者血管钙化(VC)的相关性。方法选取100例MHD患者为MHD组,100例健康者为对照组,比较2组血清PDGF-BB、Beclin1水平。按腹主动脉钙化评分(AACS)将MHD患者分为钙化组(48例)和非钙化组(52例)。分析MHD患者发生VC的影响因素;分析血清PDGF-BB、Beclin1水平预测MHD患者VC的价值。结果MHD组血清PDGF-BB水平[(90.57±31.64)pg/mL]高于对照组[(41.78±13.83)pg/mL],血清Beclin1水平[(2.02±0.68)ng/mL]低于对照组[(3.09±1.04)ng/mL],差异有统计学意义(P<0.05)。血磷、PDGF-BB、血钙、TG是影响MHD患者发生VC的危险因素(P<0.05),Beclin1是影响MHD患者发生VC的保护因素(P<0.05)。血清PDGF-BB、Beclin1水平预测MHD患者VC的曲线下面积(AUC)分别为0.885、0.832;血清PDGF-BB、Beclin1水平联合预测MHD患者VC的AUC为0.932,敏感度为85.4%,特异度为92.3%。结论MHD患者血清PDGF-BB水平较高,Beclin1水平较低,两者均与VC相关。血清PDGF-BB、Beclin1联合预测可能有助于临床预防、评估MHD患者并发VC。Objective To investigate the correlations of serum platelet-derived growth factor-BB(PDGF-BB) and autophagy-related molecule Beclin1 with vascular calcification(VC) in patients undergoing maintenance hemodialysis(MHD). Methods A total of 100 MHD patients were selected as MHD group, and 100 healthy people were selected as control group. The levels of serum PDGF-BB and Beclin1 were compared between the two groups. According to Abdominal Aortic Calcification Score(AACS), MHD patients were divided into calcification group(48 cases) and non-calcification group(52 cases). The influencing factors of VC in MHD patients were analyzed;the value of serum PDGF-BB and Beclin1 levels in predicting VC in MHD patients were analyzed. Results The level of serum PDGF-BB in the MHD group [(90.57±31.64) pg/mL] was significantly higher than that in the control group [(41.78±13.83) pg/mL], and the level of Beclin1 in MHD group [(2.02±0.68) ng/mL] was significantly lower than that in the control group [(3.09±1.04) ng/mL](P<0.05). Blood phosphorus, PDGF-BB, blood calcium and TG were the risk factors for VC in MHD patients(P<0.05), and Beclin1 was a protective factor for VC in MHD patients(P<0.05). The area under the curve(AUC) of serum PDGF-BB and Beclin1 levels in predicting VC in MHD patients were 0.885 and 0.832, respectively;the AUC of serum PDGF-BB and Beclin1 in combination to predict VC in MHD patients was 0. 932,the sensitivity was 85. 4%,and the specificity was 92. 3%. Conclusion The serum PDGF-BB level is higher and Beclin1 level is lower in MHD patients,both of them were related to VC. The combined prediction of serum PDGF-BB and Beclin1 may help to prevent and evaluate VC in MHD patients.

关 键 词：血小板衍生生长因子-BB 维持性血液透析 Beclin1水平 血管钙化 

分 类 号：R692[医药卫生—泌尿科学] R459.5[医药卫生—外科学]