轻度认知功能障碍患者Aβ1-42、Tau蛋白、Lp-PLA2水平变化及其与脑电图的关系  

Relationship between the changes of Aβ1-42,Tau protein,Lp-PLA2 levels and electroencephalogram in patients with mild cognitive impairment

作　　者：胡金雅 穆斌 孟祥安 HU Jinya;MU Bin;MENG Xiang'an(Department of Neurology,PetroChina Central Hospital,Langfang 065000,Hebei,China;Department of Ultrasound Medicine,PetroChina Central Hospital,Langfang 065000,Hebei,China)

机构地区：[1]河北中石油中心医院神经内科,河北廊坊065000 [2]河北中石油中心医院超声医学科,河北廊坊065000

出　　处：《检验医学》2022年第11期1044-1048,共5页Laboratory Medicine

基　　金：廊坊市科学技术研究与发展计划项目(2020013094)。

摘　　要：目的探讨轻度认知功能障碍(MCI)患者血清β-淀粉样多肽(1-42)(Aβ1-42)、Tau蛋白、脂蛋白相关磷脂酶A2(Lp-PLA2)水平的变化及其与脑电图参数的相关性。方法选取老年MCI患者80例(MCI组)、阿尔茨海默病(AD)患者80例(AD组)、健康体检者80名(正常对照组),收集所有对象的一般资料,检测其血清Aβ1-42、Tau蛋白、Lp-PLA2水平,并行脑电图检查。比较各组各项检测、检查结果的差异。采用Pearson相关分析评估各项指标之间的相关性。结果AD组、MCI组、正常对照组血清Aβ1-42水平依次升高(P<0.05),血清Tau蛋白和Lp-PLA2水平依次降低(P<0.05)。MCI组、AD组α1波、δ波、θ波脑电功率均高于正常对照组(P<0.05);AD组δ波、θ波脑电功率均高于MCI组(P<0.05);3个组α2波、β1波、β2波脑电功率差异均无统计学意义(P>0.05)。Pearson相关分析结果显示,MCI患者δ波、θ波脑电功率与Aβ1-42水平呈负相关(r值分别为-0.447、-0.482,P值分别为0.001、<0.0001),与Tau蛋白呈正相关(r值分别为0.571、0.467,P<0.0001),与Lp-PLA2水平无相关性(r值分别为0.117、0.163,P>0.05)。结论老年MCI患者Aβ1-42、Tau蛋白和Lp-PLA2水平会发生异常变化,且与脑电图参数有一定的相关性。Objective To investigate the changes of serum amyloidβ-protien(Aβ)1-42,Tau protein,lipoprotein-related phospholipase A2(Lp-PLA2)and electroencephalogram parameters in patients with mild cognitive impairment(MCI).Methods Totally,80 elderly MCI patients,80 Alzheimer's disease(AD)patients and 80 healthy subjects(healthy control group)were enrolled.The general data were collected,and serum Aβ1-42,Tau,Lp-PLA2 levels and electroencephalogram were determined and performed.The result difference was compared.The correlations between the indicators were assessed by Pearson correlation analysis.Results Serum Aβ1-42 levels were increased successively in AD,MCI and healthy control groups(P<0.05),and serum Tau and Lp-PLA2 levels were decreased successively(P<0.05).Theα1 waves,δwaves andθwaves in MCI and AD groups were higher than those in healthy control group(P<0.05).Theδwave andθwave in AD group were higher than those in MCI group(P<0.05).Theα2 wave,β1 wave andβ2 wave had no statistical significance among the 3 groups(P>0.05).Pearson correlation analysis showed thatδwave andθwave were negatively correlated with Aβ1-42(r values were-0.447 and-0.482,P=0.001 and P<0.0001,respectively),they were positively correlated with Tau(r values were 0.571 and 0.467,P<0.0001,respectively),and there was no correlation with Lp-PLA2 levels(r values were 0.117 and 0.163,P>0.05,respectively).Conclusions The Aβ1-42,Tau and Lp-PLA2 levels may change abnormally in elderly MCI patients,and it may affect the electroencephalogram parameters.

关 键 词：β-淀粉样多肽(1-42) TAU蛋白 脂蛋白相关磷脂酶A2 脑电图 轻度认知功能障碍 

分 类 号：R446.1[医药卫生—诊断学]