生肌象皮膏治疗慢性下肢溃疡疗效观察  

Observation of Curative Efficacy of Shengji Xiangpi Plaster(生肌象皮膏) in Treatment of Chronic Lower Limbs Ulcer

作　　者：骆树林 钱承美 花双林 朱童 LUO Shulin;QIAN Chengmei;HUA Shuanglin;ZHU Tong(Department of Orthopaedics,Jiangyan Hospital of Traditional Chinese Medicine in Taizhou City,Jiangsu province,Taizhou 225500,China)

机构地区：[1]江苏省泰州市姜堰中医院骨科,江苏泰州225500

出　　处：《山东中医杂志》2022年第12期1316-1320,共5页Shandong Journal of Traditional Chinese Medicine

基　　金：江苏省中医药科技发展计划项目(编号:YB2020092)。

摘　　要：目的:观察生肌象皮膏治疗慢性下肢溃疡的临床疗效。方法:选取慢性下肢溃疡患者106例,按随机数字表法分为对照组和观察组各53例。对照组采用灭菌凡士林纱布加压包扎创面治疗,观察组采用生肌象皮膏外敷治疗,两组均治疗1个月。观察两组治疗1个月后的疗效和治疗期间溃疡愈合指标水平,比较两组治疗前和治疗1个月后血清血管内皮生长因子(VEGF)、白细胞介素-1β(IL-1β)、转化生长因子-β1(TGF-β1)水平及创面愈合指标水平。结果:治疗1个月后,对照组、观察组总有效率分别为75.47%、90.57%,两组临床疗效比较,差异有统计学意义(P<0.05)。治疗1个月后,对照组血清IL-1β水平较治疗前升高(P<0.05),且高于观察组(P<0.05);两组血清VEGF、TGF-β1水平较治疗前均升高(P<0.05),且观察组高于对照组(P<0.05)。治疗期间,观察组生肌时间、腐肉净化时间、愈合时间均短于对照组(P<0.05)。治疗1个月后,两组溃疡深度、水肿性质、水肿程度、创周温度、创周肤色评分较治疗前均降低(P<0.05),且观察组上述评分均低于对照组(P<0.05)。结论:生肌象皮膏治疗慢性下肢溃疡,可有效促进血清VEGF、TGF-β1水平升高,抑制IL-1β合成,控制机体炎症反应,促进溃疡创面愈合,疗效较好。Objective:To observe the clinical curative efficacy of Shengji Xiangpi Plaster(生肌象皮膏)in treatment of chronic lower limbs ulcer.Methods:A total of 106 patients with chronic lower limbs ulcer were divided into control group and observation group by random number table method,with 53 cases in each group.The control group was treated with vaseline gauze pressure dressing on the wounds,while the observation group was treated with external application of Shengji Xiangpi Plaster.Both groups were treated for 1 month.The curative efficacy after 1 month of treat-ment and levels of ulcer healing indicators during the treatment of the two groups were observed,and the levels of serum vascular endothelial growth factor(VEGF),interleukin-1β(IL-1β),transforming growth factor-β1(TGF-β1)and wound healing indicators of the two groups were compared before treatment and after 1 month of treatment.Results:After 1 month of treatment,the total effective rate of the control group was 75.47%,and that of the observation group was 90.57%.The difference of clinical curative efficacy between the two groups was statistically significant(P<0.05).After 1 month of treatment,the level of serum IL-1βin the control group was higher than that before treatment,and compared with that of the observation group,it was also higher(P<0.05).After 1 month of treatment,the levels of serum VEGF and TGF-β1 in the two groups were all higher than those before treatment(P<0.05),and those in the observation group were higher than those in the control group(P<0.05).During the treatment,the muscle generation time,decontamination time,and ulcer healing time of the observation group was shorter than those of the control group(P<0.05).After 1 month of treatment,the scores of ulcer depth,edema quality,edema degree,temperature around the wounds,and skin color around the wounds in both groups were lower than those before treatment(P<0.05),and those in the control group were lower than those in the observation group(P<0.05).Conclusions:In the treatment of chr

关 键 词：慢性下肢溃疡 生肌象皮膏 凡士林 血管内皮生长因子 白细胞介素-1Β 转化生长因子-Β1 愈合时间 

分 类 号：R275[医药卫生—中医皮科]