血脂异常对非肥胖不孕患者IVF/ICSI妊娠结局的影响  

Effect of dyslipidemia on pregnancy outcome of non-obese infertile patients treated with IVF/ICSI

作　　者：孙玉红 李云 黎淑贞[1] 黎平[1] SUN Yu-hong;LI Yun;LI Shu-zhen;LI Ping(Reproductive Medical Center of Jiangmen Central Hospital,Jiangmen 529030)

机构地区：[1]江门市中心医院生殖中心,江门529030

出　　处：《生殖医学杂志》2022年第12期1706-1711,共6页Journal of Reproductive Medicine

基　　金：江门市科技计划项目(2020020300760003776)。

摘　　要：目的探讨在非肥胖不孕人群中血脂异常对IVF/ICSI助孕妊娠结局的影响。方法回顾性分析2020年10月至2021年12月于江门市中心医院生殖医学中心首次行IVF/ICSI助孕治疗的426例患者的临床资料。依据血脂正常与否分为2组:血脂异常组156例,血脂正常组(对照组)270例。比较分析两组患者的一般情况和妊娠结局。结果两组患者年龄、不孕年限、抗苗勒管激素(AMH)水平、基础窦卵泡数(AFC)、基础卵泡刺激素(bFSH)、Gn用量、获卵数、受精率、可利用胚胎数、优质胚胎率、种植率、临床妊娠率以及早期流产率差异均无统计学意义(P>0.05)。血脂异常组患者的BMI[(21.99±2.56)kg/m^(2)vs.(21.22±2.62)kg/m^(2),P=0.003]、HCG日的子宫内膜厚度[(11.68±3.22)mm vs.(11.04±2.67)mm,P=0.049]、新鲜周期平均移植胚胎数[(1.45±0.50)个vs.(1.29±0.46)个,P=0.005]均显著高于对照组。进一步Logistic回归分析校正相关混杂因素后,结果显示临床妊娠率主要受患者AFC数量[OR=1.126,95%CI(1.046,1.213),P=0.002]及移植胚胎数量[OR=2.121,95%CI(1.157,3.888),P=0.015]影响,而与其他因素包括血脂水平无关(P>0.05)。结论在非肥胖不孕人群中,未观察到血脂异常对IVF/ICSI妊娠结局产生明显影响。Objective:To investigate the effect of dyslipidemia on pregnancy outcome of non-obese infertile patients treated with IVF/ICSI.Methods:The clinical data of 426 patients who underwent IVF/ICSI for the first time in the reproductive medicine department of Jiangmen Central Hospital from October 2020 to December 2021 were analyzed retrospectively.According to whether the blood lipid was normal or not,they were divided into two groups:abnormal blood lipid group(n=156)and normal blood lipid group(control group)(n=270).The general conditions and pregnancy outcomes of the two groups were compared and analyzed.Results:There were no significant differences in age,duration of infertility,anti-Müllerian hormone(AMH)level,bilateral antral follicle count(AFC),basic FSH(bFSH)level,total gonadotropin(Gn)dose used,number of retrieved oocytes,fertilization rate,number of available embryos,high-quality embryo rate,implantation rate,clinical pregnancy rate and early abortion rate between the two groups(P>0.05).Compared with the control group,BMI[(21.99±2.56)kg/m^(2)vs.(21.22±2.62)kg/m 2,P=0.003],endometrial thickness on HCG day[(11.68±3.22)mm vs.(11.04±2.67)mm,P=0.049]and the number of embryos transferred[(1.45±0.50)vs.(1.29±0.46),P=0.005]in patients with dyslipidemia were increased significantly.Furthermore,after correction of relevant confounding factors,logistic regression analysis showed that the clinical pregnancy rate was mainly affected by the AFC[OR=1.126,95%CI(1.046,1.213),P=0.002]and the number of transferred embryos[OR=2.121,95%CI(1.157,3.888),P=0.015],but it was not related with other factors including blood lipid level(P>0.05).Conclusions:No significant effect of dyslipidemia on IVF/ICSI pregnancy outcome was observed in non-obese infertile women.

关 键 词：血脂异常 不孕 辅助生殖技术 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学]