不同时间使用来曲唑对Ⅱ型排卵障碍患者促排卵效果的研究  

Effect of different time using letrozole on ovulation induction in patients with typell ovulation disorder

作　　者：刘玲 汤鲜[1] 张先平[1] 彭露 贺育兰[1] 廖婷 谢巍伟 Liu Ling;Tang Xian;Zhang Xianping;Peng Lu;He Yulan;Liao Ting;Xie Weiwei(Department of Obstetrics and Gynecology,Loudi Central Hospital of Hunan Province,Loudi 417099,China)

机构地区：[1]湖南省娄底市中心医院妇产科,湖南娄底417099

出　　处：《实用妇科内分泌电子杂志》2022年第15期1-4,共4页Electronic Journal of Practical Gynecological Endocrinology

基　　金：湖南省娄底市中心医院2020年度院级科研课题(编号Y2020-02)。

摘　　要：目的探讨Ⅱ型排卵障碍患者不同时间开始服用来曲唑的促排卵治疗效果。方法选择60例Ⅱ型排卵障碍患者,根据随机数字表法分为对照组与研究组,每组30例。研究组和对照组患者分别于月经第3天和第5天给予来曲唑。统计分析两组患者人绒毛膜促性腺激素(HCG)注射日激素水平变化及内膜厚度、促排卵效果、妊娠情况、排卵时间。结果治疗后,两组HCG注射日促黄体生成素(LH)、雌二醇(E_(2))、孕酮(P)水平比较,差异均无统计学意义(P>0.05);HCG注射日及排卵日内膜厚度比较,差异均无统计学意义(P>0.05)。虽然研究组排卵率低于对照组,但两组比较差异无统计学意义(P>0.05)。研究组排卵时间早于对照组,两组比较差异有统计学意义(P<0.05)。两组妊娠成功率比较差异无统计学意义(P>0.05)。结论Ⅱ型排卵障碍患者在月经第3天或第5天开始服用来曲唑,对体内生殖激素、内膜厚度的影响相似,其排卵率和妊娠率均无明显差别;但月经第3天开始服用来曲唑,其排卵时间早于月经第5天开始,值得临床推广与应用。Objective To investigate the effect of different time starting letrozole on ovulation induction in patients with typellovulation disorder.Methods A total of 60 patients with typellovulation disorder were randomly divided into control group and study group,with 30 cases in each group.Letrozole was given to the study group and the control group on the third and fifth days of menstruation,respectively.The changes of hormone levels on the day of human chorionic gonadotropin(HCG)injection,intimal thickness,effect of ovulation induction,pregnancy status and ovulation time of the two groups were statistically analyzed.Results After treatment,there were no significant differences in LH,E_(2) and P levels between the two groups on the day of HCG injection(P>0.05).There was no significant difference in intimal thickness between HCG injection day and ovulation day(P>0.05).Although the ovulation rate of the study group was lower than that of the control group,there was no significant difference between the two groups(P>0.05).The ovulation time of the study group was earlier than that of the control group,and the difference between the two groups was statistically significant(P<0.05).There was no significant difference in pregnancy success rate between the two groups(P>0.05).Conclusion Taking letrozole on the 3rd or 5th day of menstruation in patients with type Ⅱ ovulation disorder has similar effects on reproductive hormones and intimal thickness,and there is no significant difference in ovulation rate and pregnancy rate.However,when taking letrozole on the third day of menstruation,the ovulation time was earlier than that on the fifth day of menstruation,which is worthy of clinical promotion and application.

关 键 词：来曲唑 排卵障碍 促排卵 妊娠 

分 类 号：R711.75[医药卫生—妇产科学]