稀土纳米材料在高分辨活体成像及诊疗中的应用  

High-resolution in vivo Imaging,Diagnosis and Treatment Applications of Rare-earth-based Nanomaterials

作　　者：张钤 刘雅薇 王帆 刘凯[1,2] 张洪杰 ZHANG Qian;LIU Yawei;WANG Fan;LIU Kai;ZHANG Hongjie(Engineering Research Center of Advanced Rare Earth Materials,Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084,China;State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China)

机构地区：[1]清华大学化学系,稀土新材料教育部工程研究中心,北京100084 [2]中国科学院长春应用化学研究所,稀土资源利用国家重点实验室,长春130022

出　　处：《高等学校化学学报》2022年第12期138-153,共16页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:22020102003)资助。

摘　　要：荧光成像具有时空分辨率高、反馈快、非侵入和无电离辐射等优点,是一种重要的生物成像技术.与传统用于荧光成像的可见光和近红外一区(NIR-I,600~950 nm)相比,近红外二区(NIR-Ⅱ,1000~1700 nm)窗口具有低生物组织散射系数和低生物自发荧光,采用NIR-Ⅱ光进行活体荧光成像能有效提高成像的分辨率、信噪比和穿透深度.稀土纳米颗粒(RENPs)具有大斯托克斯位移、高化学稳定性、可调的荧光寿命以及较窄的发射带,是一种重要的荧光成像探针.近年来,一系列具有优异的NIR-Ⅱ发光性能的稀土纳米材料被用于高分辨活体荧光成像.本文综合评述了近年来RENPs用于高分辨活体成像及诊疗中的研究进展,概述了RENPs的掺杂调控、基质晶格选择和复合敏化等NIR-Ⅱ发光增强策略,介绍了其在多种生物医学场景中的靶向聚集、荧光传感和疾病治疗等功能,并总结了其在多路成像、多模态成像和疾病诊疗中的应用.最后,简要分析了RENPs在未来生物医学应用中面临的挑战和发展的方向.Fluorescence imaging with the advantages of high spatiotemporal resolution,fast feedback,non-invasive⁃ness,and no ionizing radiation is an important bioimaging technology.Compared with the traditionally used visible and first near-infrared(NIR-I,650—950 nm)windows,the second near-infrared(NIR-Ⅱ,1000—1700 nm)window has lower scattering coefficients and biological autofluorescence,thus effectively improving the resolution,signal-tonoise ratio and penetration depth of bioimaging.Rare-earth-based nanoparticles(RENPs)possess large Stokes shift,high chemical stability,tunable fluorescence lifetimes,and narrow emission bands,making them important fluores⁃cent imaging probes.In recent years,a series of RENPs with excellent NIR-Ⅱfluorescence properties have been developed and applied to high-resolution in vivo fluorescence imaging,disease diagnosis and therapy.Herein,the re⁃cent research progress of RENPs in high-resolution in vivo fluorescence imaging and theranostics is comprehensively reviewed.Strategies for NIR-Ⅱemission enhancement of RENPs,such as dopant regulation,matrix lattice selection,and composite sensitization,are summarized.And their functions of targeting accumulation,fluorescence sensing,disease diagnosis and treatment in multiple biomedical scenes are also introduced.Moreover,their applications in multiplexed imaging,multimodal imaging,and disease diagnosis and treatment are highlighted.Finally,a brief per⁃spective for the future development and challenges of RENPs in biomedical applications is presented.

关 键 词：稀土纳米材料 高分辨荧光成像 活体生物成像 生物医学应用 

分 类 号：O614[理学—无机化学] Q334[理学—化学]