基于DNA与上转换纳米颗粒相结合的生物传感与成像研究进展  

Advances in Biosensing and Imaging Based on the Integration of DNA and Upconversion Nanoparticles

作　　者：赵恒智 余方志 李翔菲 李乐乐 ZHAO Hengzhi;YU Fangzhi;LI Xiangfei;LI Lele(CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,Beijing 100190,China)

机构地区：[1]国家纳米科学中心,中国科学院纳米生物效应与安全性重点实验室,北京100190

出　　处：《高等学校化学学报》2022年第12期282-289,共8页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:22125402)资助。

摘　　要：脱氧核糖核酸(DNA)的分子识别特性与功能使其在生物传感与成像领域得到了广泛应用.另一方面,得益于自身独特的光学性质,镧系元素掺杂的上转换纳米颗粒在生物医学应用中备受关注.特别地,二者的有机结合可产生新的性质与功能,在生物传感与成像领域展现出优势,推动了该领域的发展.本文综合评述了基于DNA与上转换纳米颗粒相结合的生物传感与成像技术的研究进展,重点聚焦于相关方法的分类与设计原理,简要概述了相关的应用研究,并对该领域目前存在的挑战与未来的发展前景进行了讨论.Deoxyribonucleic aicd(DNA)have been widely used in biosensing and imaging because of their molecu⁃lar recognition properties and functions.Lanthanide-doped upconversion nanoparticles(UCNPs)have also attracted extensive attention in biomedical applications due to their unique optical properties.In particular,the elegant integra⁃tion of UCNPs and DNA holds many unparalleled features and functions,advancing the development in the field of biological sensing and imaging.In this review,we summarized the advances in biosensing and imaging based on the integration of DNA and UCNPs.We mainly focused on the design principles of the developed methods,briefly intro⁃duced their applications,and discussed the current challenges and future perspectives in this field.

关 键 词：上转换纳米颗粒 脱氧核糖核酸 生物传感器 生物成像 纳米探针 

分 类 号：O614[理学—无机化学] O657[理学—化学]