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作 者:张恩东 吕凤婷[1] 黄一鸣 白昊天[1] 王树[1] ZHANG Endong;LYU Fengting;HUANG Yiming;BAI Haotian;WANG Shu(Beijing National Laboratory for Molecular Sciences,Key Laboratory of Organic Solids,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China)
机构地区:[1]北京分子科学国家研究中心,有机固体院重点实验室,中国科学院化学研究所,北京100190
出 处:《高等学校化学学报》2022年第12期318-327,共10页Chemical Journal of Chinese Universities
基 金:国家自然科学基金(批准号:22022705,22020102005,22074150)资助.
摘 要:纳米催化剂因其经济、稳定以及可量产等优势,实现了细胞内原位催化反应,为分子水平人工调控细胞功能提供了可能.人工纳米催化剂优异的催化性能使其在不同生理和病理条件下成功用于诊断成像和治疗.本文综合评述了具有天然酶活性的纳米催化剂在癌症和氧化应激治疗以及基于纳米催化剂介导的细胞内原位催化反应的精准诊断成像方面的主要研究进展,并对纳米催化剂在未来生物医药领域应用中面临的挑战和机遇进行了展望.Nanocatalysts offer possibilities to realize intracellular in situ catalytic reactions for artificially regulating cellular activities at the molecular level.Artificial nanocatalysts have shown excellent catalytic performances in diag⁃nostic imaging and treatment under different physiological and pathological conditions due to their low cost,good stability,and safe yield production.In this review,we summarized the key progress in nanocatalysts with the activities of natural enzymes for cancer and oxidative stress treatments,and the proposed concept of accurate diag⁃nostic imaging based on nanocatalyst-mediated intracellular catalytic reaction,as well as the challenges and pros⁃pects of nanocatalysts for further applications in the health care field were discussed.
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