中药成分通过干预自噬实现肿瘤放射增敏的研究进展  

Research Progress of Traditional Chinese Medicine(TCM)Regulating Autophagy Pathway to Enhance Sensitization Effect of Tumor Radiotherapy

作　　者：林洋 于大海[1] 鹿红[1] 黄腾 陈乐君 赵悦欣 LIN Yang;YU Dahai;LU Hong;HUANG Teng;CHEN Lejun;ZHAO Yuexin(Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Nanjing 210029,China)

机构地区：[1]南京中医药大学附属医院,南京210029

出　　处：《中医药临床杂志》2022年第10期1972-1975,共4页Clinical Journal of Traditional Chinese Medicine

基　　金：江苏省中医药管理局科技项目(YB201815);江苏省研究生科研创新计划项目(KYCX21_1707);江苏省中医院科技项目(Y21022)。

摘　　要：自噬是一种将细胞质成分在溶酶体内降解并将产生的大分子成分回收循环利用的细胞过程。放射治疗是治疗多种癌症以杀死或控制恶性肿瘤细胞的重要手段,而肿瘤放疗抵抗限制了放疗的疗效,开发新的药物以提高放射敏感性是亟待解决的重要难题。一些中药成分可通过干预自噬达到放疗增敏的效果,但目前的研究局限于细胞层面。Autophagy is a cellular process that degrades cytoplasmic constituents within lysosomes and recycles the resulting macromolecular constituents for recycling.Radiotherapy is an important means of treating a variety of cancers to kill or control malignant tumor cells,while tumor radiotherapy resistance limits the efficacy of radiotherapy,and the development of new drugs to improve radio-sensitivity is an important urgent problem.Some TCM components can achieve the effect of radio-sensitization by intervening in autophagy,but current research is limited to the cellular level.

关 键 词：中药成分 自噬 放射增敏 肿瘤 

分 类 号：R273[医药卫生—中西医结合]