白细胞介素-25在组织损伤修复中的作用研究进展  

Research progress on the role of interleukin-25 in tissue damage repair

作　　者：谭静 李平 曹旗 黄青松 TAN Jing;LI Ping;CAO Qi;HUANG Qingsong(Department of Internal Medicine,Clinical Medical College,Henan Medical College,Zhengzhou 451191,Henan Province,China;Henan Provincial Key Laboratory of Immunization and Targeted Drugs,School of Medical Laboratory,Xinxiang Medical University,Xinxiang 453003,Henan Province,China)

机构地区：[1]河南医学高等专科学校临床医学院内科教研室,河南郑州451191 [2]新乡医学院医学检验学院河南省免疫与靶向药物重点实验室,河南新乡453003

出　　处：《新乡医学院学报》2022年第12期1178-1182,共5页Journal of Xinxiang Medical University

基　　金：国家自然科学基金资助项目(编号:81200506,81570624,81770721,U1804167);河南省高等学校重点科研项目资助项目(编号:21A320008)。

摘　　要：白细胞介素(IL)-25又称IL-17E,是IL-17细胞因子家族的一员,主要由上皮细胞和天然免疫细胞产生。IL-25可诱导上皮细胞和2型淋巴细胞中下游信号反应,从而启动、维持Ⅱ型免疫反应。IL-25在肾脏、肝脏、肺部和肠道等组织损伤修复中发挥重要的作用。本文综述了IL-25通过调控不同的信号通路对组织损伤修复的作用研究进展。Interleukin(IL)-25,also known as IL-17E,is a member of the IL-17 cytokine family,which is mainly produced by epithelial cells and natural immune cells.IL-25 can induce signal response in the middle and lower reaches of epithelial cells and type 2 lymphocytes,thus initiating and maintaining typeⅡimmune response.IL-25 plays an important role in the repair of kidney,liver,lung and intestine injury.This article reviews the research progress of IL-25 on tissue damage repair through regulating different signal pathways.

关 键 词：白细胞介素-25 肾脏损伤 肝脏损伤 肺部损伤 肠道损伤 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]