Integrative modeling of the cell  

作　　者：Xianni Zhong Jihui Zhao Liping Sun 

机构地区：[1]Human Institute,ShanghaiTech University,Shanghai 201210,China [2]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

出　　处：《Acta Biochimica et Biophysica Sinica》2022年第9期1213-1221,共9页生物化学与生物物理学报（英文版）

基　　金：the grant from Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at ShanghaiTech University,Shanghai Municipal Government and ShanghaiTech University.

摘　　要：A whole-cell model represents certain aspects of the cell structure and/or function.Due to the high complexity of the cell,an integrative modeling approach is often taken to utilize all available information including experimental data,prior knowledge and prior models.In this review,we summarize an emerging workflow of whole-cell modeling into five steps:(i)gather information;(ii)represent the modeled system into modules;(ili)translate input information into scoring function;(iv)sample the whole-cell model;(v)validate and interpret the model.In particular,we propose the integrative modeling of the cell by combining available(whole-cell)models to maximize the accuracy,precision,and completeness.In addition,we list quantitative predictions of various aspects of cell biology from existing whole-cell models.Moreover,we discuss the remaining challenges and future directions,and highlight the opportunity to establish an integrative spatiotemporal multi-scale whole-cell model based on a community approach.

关 键 词：whole-cell modeling integrative modeling compartment model cell biology 

分 类 号：Q2[生物学—细胞生物学]