α⁃硫辛酸升高血清硫化氢水平改善糖尿病周围神经病变的研究  

Alpha⁃lipoic acid alleviates diabetic peripheral neuropathy by elevating serum hydrogen sulfide level

作　　者：邱轩[1] 陈雅洁 田思宇 阎红伶 孟怡媚 李钰 刘宽芝[1] QIU Xuan;CHEN Yajie;TIAN Siyu(Department of Endocrinology,Third Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第三医院内分泌科,石家庄050000 [2]河北医科大学第三医院肝胆外科,石家庄050000 [3]河北医科大学研究生学院

出　　处：《中国糖尿病杂志》2022年第10期728-732,共5页Chinese Journal of Diabetes

基　　金：河北省自然科学基金(H2020206490);河北省医学科学研究课题计划项目(20190640);河北省政府资助省级临床医学优秀人才项目(2017年)。

摘　　要：目的探讨α-硫辛酸(AL)升高血清硫化氢(H_(2)S)水平改善糖尿病周围神经病变(DPN)的机制。方法选取2019年1~12月于河北医科大学第三医院内分泌科住院的T2DM患者231例,分为单纯T2DM组(T2DM,n=109)和合并DPN组(DPN,n=122)。DPN组再分为常规治疗亚组(Con,n=64)和AL治疗亚组(AL,n=58)。检测各组血清H_(2)S水平及相关生化指标,进行神经系统症状评分(NSS)和密歇根糖尿病神经病变评分(MDNS),测量感觉神经传导速度(SCV)、运动神经传导速度(MCV)。结果DPN组血清H_(2)S水平低于T2DM组[3.67(3.01,4.57)vs 4.00(3.32,5.11)μmol/L,P=0.016]。Spearman相关分析显示,DPN患者血清H_(2)S水平与SCV、MCV呈正相关(P<0.05),与NSS、MDNS呈负相关,(P<0.05)。AL治疗2周后,AL亚组血清H_(2)S水平变化值高于Con亚组[0.96(0.24,2.13)vs 0.34(0.08,0.93)μmol/L,P=0.001]。结论AL可通过升高DPN患者血清H_(2)S水平改善临床症状。Objective To explore whether alpha-lipoic(AL)acid ameliorates diabetic peripheral neuropathy(DPN)by elevating serumhydrogen sulfide(H_(2)S)level.Methods 231 in patients with type 2 diabetes mellitus(T2DM)in Third Hospital of Hebei Medical University from January 2019 to December 2019 were recruited in this study and divided into T2DM group(T2DM,n=109)and DPN group(n=122).The DPN group was split into conventional therapy subgroup(Con,n=64)and AL subgroup(AL,n=58).Serum H_(2)S level and other correlated biochemical indexes were measured.Neuropathy symptom score(NSS)and Michigan diabetic neuropathy score(MDNS)were evaluated.Sensory/motor nerve conduction velocity(SCV/MCV)were detected.Results The serum H_(2)S level of DPN group was lower than that of T2DM group[3.67(3.01,4.57)vs 4.00(3.32,5.11)μmol/L,P=0.016].Spearman correlation analysis showed that serum H_(2)S in patients with DPN was positively correlated with SCV and MCV(P<0.05),and negatively correlated with NSS and mDNS(P<0.05).After two weeks treatment,the increment of serum H_(2)S level in AL subgroup was higher than that in Con subgroup[0.96(0.24,2.13)vs 0.34(0.08,0.93)μmol/L,P=0.001].ConclusionAL could alleviate DPN by elevating serum H_(2)S level.

关 键 词：Α-硫辛酸 糖尿病周围神经病变 硫化氢 

分 类 号：R587.2[医药卫生—内分泌]