雌孕激素序贯疗法联合Floey球囊预防胎物残留清除术后宫腔粘连的临床研究  

Clinical study of sequential estrogen progesterone therapy combined with Floey balloon to prevent intrauterine adhesion after removal of fetal material residue

作　　者：伊婷 杨静[1] 刘雁林[1] YI Ting;YANG Jing;LIU Yanlin(Department of Gynecology,The Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830011,China)

机构地区：[1]新疆医科大学第五附属医院妇科,新疆乌鲁木齐830011

出　　处：《中国优生与遗传杂志》2022年第10期1786-1790,共5页Chinese Journal of Birth Health & Heredity

基　　金：新疆维吾尔自治区自然科学基金项目(2020D01C221)。

摘　　要：目的 分析雌孕激素序贯疗法联合Floey球囊预防胎物残留清除术后宫腔粘连的临床研究。方法 选取2020年6月至2021年6月新疆医科大学第五附属医院收治的胎物残留清除术后患者100例,按随机数字表法分为两组。两组患者术后均接受常规治疗,对照组(50例)患者在此基础上术后使用Foley球囊,观察组(50例)患者在对照组的基础上联合雌孕激素序贯疗法。比较两组患者临床疗效;比较两组患者临床相关指标;比较两组患者治疗前、治疗3个月后子宫内膜厚度、搏动指数、阻力指数、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、转化生长因子-β(TGF-β)、雌二醇、孕酮水平。结果 观察组临床总有效率为98.00%,高于对照组的84.00%(P<0.05);观察组腹痛持续时间、阴道出血时间、住院时间短于对照组,阴道出血量少于对照组(P<0.05);与治疗前比,治疗3个月后两组患者子宫内膜厚度均增加,且观察组厚于对照组,雌二醇、孕酮均升高,且观察组高于对照组,搏动指数、阻力指数、血清IL-6、IL-8、TNF-α、TGF-β均降低,且观察组低于对照组(P<0.05)。结论 雌孕激素序贯疗法联合Floey球囊可预防胎物残留清除术后患者发生宫腔粘连,利于缓解炎症反应,改善子宫内膜环境,提高雌孕激素水平,利于患者预后。Objective To analyze the clinical study of sequential estrogen progesterone therapy combined with Floey balloon to prevent intrauterine adhesion after removal of fetal material residue. Methods A total of 100 patients admitted to the Fifth Affiliated Hospital of Xinjiang Medical University from June 2020 to June 2021 after removal of fetal remains were selected and divided into two groups according to the random number table method. Patients in both groups received conventional treatment after surgery, and patients in the control group(50 cases) were treated with Foley balloon after surgery, while patients in the observation group(50 cases) were treated with sequential estrogen progesterone therapy on the basis of the control group. The clinical efficacy of the two groups was compared. Clinical indicators of the two groups were compared.Endometrial thickness, pulsatile index, resistance index, interleukin-6(IL-6), interleukin-8(IL-8), tumor necrosis factor-α(TNF-α), transforming growth factor-β(TGF-β), estradiol, progesterone levels in two groups were compared before treatment and three months after treatment. Results The total effective rate of observation group was 98.00%, which was higher than that of control group(84.00%)(P<0.05). The duration of abdominal pain, vaginal bleeding and hospital stay in observation group were shorter than those in control group, the amount of vaginal bleeding in observation group was less than that in control group(P<0.05). Compared with before treatment, three months after treatment, endometrial thickness was increased in two groups, and the observation group was higher than the control group, pulbeat index and resistance index were decreased, and the observation group was lower than the control group(P<0.05). Compared with before treatment, serum IL-6, IL-8, TNF-α and TGF-β were decreased in two groups after three months of treatment, and the observation group was lower than the control group(P<0.05). Compared with before treatment, estradiol and progesterone in two group

关 键 词：胎物残留清除术 宫腔粘连 雌孕激素序贯疗法 Floey球囊 

分 类 号：R713.4[医药卫生—妇产科学]