二苯基二硒醚的药理作用及其机制研究进展  

Research progress on pharmacological action and the mechanism of diphenyl diselenide

作　　者：王星 周军 WANG Xing;ZHOU Jun(Department of Pharmacy,North Sichuan Medical College,Nanchong 637100,China;Hubei Key Laboratory of Bioinorganic Chemistry&Materia Medica,Hubei Engineering Research Center for Biomaterials and Medical Protective Materials,School of Chemistry and Chemical Engineering,Huazhong University of Science and Technology,Wuhan 430074,China;Shenzhen Huazhong University of Science and Technology Research Institute,Shenzhen 518057,China)

机构地区：[1]川北医学院药学院,四川南充637100 [2]华中科技大学化学与化工学院,生物无机化学与药物湖北省重点实验室,生物医用与防护材料湖北省工程研究中心,湖北武汉430074 [3]深圳华中科技大学研究院,广东深圳518057

出　　处：《药学学报》2022年第11期3259-3267,共9页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(31972920,31270870);湖北省揭榜制技术创新专项重大项目(2019A EE007);深圳市基础研究重点项目(JCYJ20200109105836705);川北医学院博士科研启动基金(CBY21-QD16);川北医学院药学一流学科群资助项目(CBY21-YLXK03)。

摘　　要：合成有机硒化合物可用作抗氧化剂、酶抑制剂、神经保护剂、抗肿瘤剂、抗感染剂及免疫调节剂。二苯基二硒醚(diphenyl diselenide,DPDS)是结构简单又稳定的合成有机硒化合物,毒性比无机硒和大多数有机硒化合物小。DPDS具有很强的谷胱甘肽过氧化物酶模拟活性,参与硫氧还蛋白还原酶催化反应,并激活核因子E2相关因子2(nuclear factor E2 associated factor 2,Nrf2)/Kelch样ECH关联蛋白1(Kelch like epichlorohydrin associated protein-1,Keap1)信号通路,因此具有强抗氧化性。DPDS已在多种动物模型和细胞模型中被证实具有抗炎、抗糖尿病、抗真菌、神经保护、抗肿瘤、护肝、肾脏保护和心血管保护作用等多种药理活性。本文通过梳理相关研究成果,将DPDS的理化性质、主要药理作用及其机制的研究进展进行综述,以期为今后DPDS的研究与合理开发应用提供参考。Synthetic organoselenium compounds can be used as antioxidants,enzyme inhibitors,neuroprotective agents,antitumor agents,anti-infectious agents,and immunomodulators.Diphenyl diselenide(DPDS)is a synthetic organoselenium compound with simple and stable structure,and possesses lower toxicity than inorganic selenium and most organoselenium compounds.Moreover,DPDS has strong antioxidant properties due to its strong glutathione peroxidase-mimetic activity,involvement in thioredoxin reductase catalytic reactions,and activation of the nuclear factor E2 associated factor 2(Nrf2)/Kelch like epichlorohydrin associated protein-1(Keap1)signaling pathway.DPDS has been shown to possess a variety of pharmacological activities including anti-inflammatory,anti-diabetic,antifungal,neuroprotective,antitumor,hepatoprotective,renoprotective,and cardiovascular protective effects in a variety of animal and cellular models.This paper reviews the research progress on the physicochemical properties,main pharmacological effects and mechanisms of DPDS by compiling relevant research results,so as to provide reference for future research and reasonable development and application of DPDS.

关 键 词：硒 二苯基二硒醚 抗氧化剂 抗炎剂 降血糖剂 神经保护剂 抗肿瘤剂 

分 类 号：R966[医药卫生—药理学]