广藿香中的两个caryolane型倍半萜  

Two caryolane-type sesquiterpenoids from Pogostemon cablin(Blanco)Benth.

作　　者：李淑仪 冯玉梅 宿露 刘丹[1] 李蓉涛[1] 李洪梅[1] LI Shu-yi;FENG Yu-mei;SU Lu;LIU Dan;LI Rong-tao;LI Hong-mei(Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500,China)

机构地区：[1]昆明理工大学生命科学与技术学院,云南昆明650500

出　　处：《药学学报》2022年第11期3361-3364,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(32060106);云南省应用基础研究计划项目(2019FB025);昆明理工大学新型抗流感药物研发省创新团队(2019HC018)。

摘　　要：采用硅胶、凝胶和高效液相色谱等色谱分离技术,从广藿香[Pogostemon cablin(Blanco)Benth.]干燥地上部分的石油醚萃取部位中分离得到两个caryolane型倍半萜。通过核磁共振和质谱等波谱学方法,化合物1和2的结构分别被鉴定为caryolanol A(1)和1α-ethoxy-9α-hydroxy-senecrassane(2),其中化合物1为新化合物,与化合物2互为C差向异构体。此外,对化合物1和2进行了体外抗流感病毒活性评价。By means of several chromatographic techniques,such as silica gel,Sephadex LH-20 and semipreparative high performance liquid chromatography(HPLC),two caryolane-type sesquiterpenoids were isolated from the petroleum ether soluble fraction of the aerial parts of Pogostemon cablin(Blanco)Benth.,and their structures were identified as caryolanol A(1)and 1α-ethoxy-9α-hydroxy-senecrassane(2)by various spectroscopic methods,including NMR and HR-ESI-MS.Compounds 1 and 2 were a pair of Cepimers,and compound 1 was a new compound.In addition,the anti-influenza virus activity of compounds 1 and 2 was evaluated.

关 键 词：广藿香 唇形科 倍半萜 caryolane 抗流感病毒 

分 类 号：R284[医药卫生—中药学]