青海省2020年1-69岁人群乙型肝炎血清流行率  

Hepatitis B seroprevalences among a 1-69-year-old population of Qinghai province in 2020

作　　者：郭子哲 阿克忠[1] 郝增平[1] 赵生仓 吴娟 丁睿尧 Guo Zizhe;A Kezhong;Hao Zengping;Zhao Shengcang;Wu Juan;Ding Ruiyao(Qinghai Provincial Center for Disease Control and Prevention,Xining 810007,Qinghai,China;Department of Public Health,Medical Institute of Qinghai University,Xining 810001,Qinghai,China)

机构地区：[1]青海省疾病预防控制中心,青海西宁810007 [2]青海大学医学部公共卫生系,青海西宁810001

出　　处：《中国疫苗和免疫》2022年第5期534-539,共6页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解青海省2020年1-69岁人群乙型肝炎(乙肝)病毒(Hepatitis B virus,HBV)血清标志物流行率。方法采用分层多阶段整群随机抽样方法,选取青海省1-69岁常住人口开展问卷调查,采集血清标本,检测乙肝表面抗原(Hepatitis B surface antigen,HBsAg)、乙肝表面抗体(Hepatitis B surface antibody,HBsAb)和乙肝核心抗体(Hepatitis B core antibody,HBcAb),分析HBV血清标志物流行率。结果共纳入1661名调查对象,HBsAg、HBsAb、HBcAb总阳性率分别为1.20%、45.57%、16.56%(标化值:1.38%、43.46%、18.12%)。1-4岁、5-14岁、15-29岁、30-69岁人群HBsAg阳性率分别为0.00%、0.00%、0.30%、2.37%(趋势χ^(2)=14.21,P=0.000),HBsAb阳性率分别为69.74%、43.33%、50.76%、37.41%(趋势χ^(2)=57.19,P=0.000),HBcAb阳性率分别为9.21%、1.67%、5.74%、28.68%(趋势χ~2=110.63,P=0.000)。结论青海省2020年1-69岁人群HBsAg阳性率明显下降,特别是1-14岁儿童下降显著。建议探索成人特别是重点或高危人群的乙肝疫苗免疫策略。Objective To determine seroprevalences of hepatitis B virus(HBV)serum markers among a 1-69-year-old population of Qinghai province in 2020.Methods We used a stratified multi-stage cluster random sampling method to select 1-69-year-olds from Qinghai in 2020 for a questionnaire-based survey.We tested serum samples for hepatitis B surface antigen(HBsAg),hepatitis B surface antibody(HBsAb),and hepatitis B core antibody(HBcAb)to determine prevalences of these HBV serum markers.Results Among the 1661 subjects,overall unadjusted HBsAg,HBsAb,and HBcAb positivity rates were 1.20%,45.57%,and 16.56%,respectively(adjusted rates were 1.38%,43.46%,and 18.12%).Among 1-4-,5-14-,15-29-,and 30-69-year-olds,HBsAg positivity rates were 0.00%,0.00%,0.30%,and 2.37%,respectively(trend χ^(2)=14.21,P=0.000),of HBsAb were 69.74%,43.33%,50.76%,and 37.41%(trend χ^(2)=57.19,P=0.000),and of HBcAb were 9.21%,1.67%,5.74%,and 28.68%(trend χ^(2)=110.63,P=0.000).Conclusions The seropositivity of HBsAg decreased significantly among 1-69-year-old people of Qinghai in 2020,especially among children aged 1-14 years.We suggest exploring hepatitis B immunization strategies for priority and high-risk adults.

关 键 词：乙型病毒性肝炎 乙型肝炎病毒 血清标志物 血清流行率 

分 类 号：R186[医药卫生—流行病学]