益气愈创汤辅助治疗湿热下注型低位肛瘘切开术后患者的临床疗效  被引量:1

Clinical effect of Yiqiyuchuang decoction in the adjuvant treatment of postoperative patients with low anal fistula of downward-flowing damp-heat type

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作  者:许圳鹏 吴燕燕[1] XU Zhenpeng;WU Yanyan(Department of Anorectal Medicine,People′s Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350004,China)

机构地区:[1]福建中医药大学附属人民医院肛肠科,福建省福州市350004

出  处:《临床合理用药杂志》2022年第33期46-49,共4页Chinese Journal of Clinical Rational Drug Use

摘  要:目的观察益气愈创汤辅助治疗湿热下注型低位肛瘘切开术后患者的临床疗效。方法选取2020年9月—2021年9月福建中医药大学附属人民医院收治的88例行肛瘘切开术治疗的湿热下注型低位肛瘘患者作为研究对象,采用随机数字表法分为西医组和中西医组,各44例。西医组患者术后采用常规治疗,中西医组在西医组基础上采用益气愈创汤辅助治疗。比较2组治疗7 d、14 d创面愈合率,创面愈合时间,治疗前及治疗14 d后疼痛、水肿、渗出、肉芽形态评分及血管内皮生长因子[血管内皮生长因子(VEGF)、转化生长因子β_(1)(TGF-β_(1))、表皮生长因子(EGF)]水平,不良反应。结果中西医组总有效率为95.45%,高于西医组的79.54%(χ^(2)=5.091,P=0.024)。中西医组治疗7 d、14 d后创面愈合率高于西医组,创面愈合时间短于西医组(P<0.01)。治疗14 d后,2组创面疼痛、水肿、渗出、肉芽形态评分低于治疗前,且中西医组低于西医组(P<0.01)。治疗14 d后,2组血清VEGF、TGF-β_(1)、EGF水平高于治疗前,且中西医组高于西医组(P<0.01)。治疗期间,患者均未发生严重不良反应。结论益气愈创汤辅助治疗湿热下注型低位肛瘘切开术后患者的效果较好,能够有效提高机体血管内皮生长因子水平,进而快速促进创面愈合,提高创面愈合率,缓解创面症状,且安全性较高。Objective To explore the clinical effect of Yiqiyuchuang decoction in the adjuvant treatment of postoperative patients with low anal fistula of downward-flowing damp-heat type.Methods A total of 88 cases of anal fistula incision postoperative patients with low anal fistula of downward-flowing damp-heat type were selected in People′s Hospital Affiliated to Fujian University of Traditional Chinese Medicine from September 2020 to September 2021,and they were divided into group A and group B,with 44 cases in each group.The group A was treated with conventional therapy,and group B was given Yiqiyuchuang decoction for adjuvant treatment based on control group.Wound healing rate after 7,14 days of treatment,wound healing time,wound symptom score and vascular endothelial growth factors(VEGF,TGF-β_(1),EGF)levels before treatment and after 14 days of treatment,incidence of adverse reactions were compared between the two groups.Results The total effective rate was 95.45%of group B,was higher than 79.54%of group A(χ^(2)=5.091,P=0.024).After 7,14 days of treatment,the wound healing rate of group B was higher than that of the group A,and wound healing time was shorter than that of group A(P<0.01).After 14 days of treatment,scores of pain,edema,exudation,granulation morphology of wound surface in the two groups were lower than those before treatment,and those in group B were lower than group A(P<0.05).After 14 days of treatment,serum levels of VEGF,TGF-β_(1) and EGF in the two groups were higher than those before treatment,and those in group B were lower than group A(P<0.01).There was no serious adverse reactions during treatment of patients.Conclusion Yiqiyuchuang decoction has a significant effect in the auxiliary treatment of postoperative patients with low-position anal fistula of damp-heat betting type,it can promote vascular endothelial growth factors,thereby rapidly promote wound healing,improving wound healing rate,relieving wound symptoms,and with high safety.

关 键 词:肛瘘 益气愈创汤 血管内皮生长因子 治疗结果 

分 类 号:R657.16[医药卫生—外科学]

 

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