反流症状评分量表中文版的信度和效度评估  

Evaluation of reliability and validity of the Chinese version of a new symptom score of laryngopharyngeal reflux disease

作　　者：韩红蕾[1] 吕秋萍[1] 刘剑锋[1] 赵建辉[1] Han Honglei;Lyu Qiuping;Liu Jianfeng;Zhao Jianhui(Department of Otorhinolaryngology Head and Neck Surgery,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院耳鼻咽喉头颈外科,北京100029

出　　处：《中华耳鼻咽喉头颈外科杂志》2022年第10期1185-1190,共6页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

摘　　要：目的建立咽喉反流性疾病(LPRD)的反流症状评分(reflux symptom score,RSS)量表中文版,评估其信度和效度。方法回顾性分析2020年11月—2021年12月就诊于中日友好医院耳鼻咽喉头颈外科的疑似LPRD患者[研究组,135例,其中男67例,女68例,年龄18~77(43.03±13.35)岁]和健康受试者[对照组,42名,其中男20名,女22名,年龄20~23(21.26±0.67)岁]资料,评估其反流症状指数(RSI)、反流体征评分(RFS)、口咽动态pH监测(Dx-pH监测)以及RSS,1周后再次评估其RSS。对确诊的LPRD患者,给予质子泵抑制剂(PPI)治疗8周,再行RSS评估。分析比较相关结果,对RSS的信度和效度进行评估。采用SPSS 18.0软件进行统计学分析。结果RSS各条目之间Cronbach′sα系数为0.77。1周后再次评估上述各条目,2次评估的P值均小于0.05。RSS与Dx-pH监测结果对照显示,诊断符合率为84.44%(114/135),阳性预测值为85.71%(114/133)。确诊LPRD患者PPI治疗后的RSS明显降低[治疗前(84.79±42.50)分,治疗后(20.11±22.82)分,t=-10.54,P<0.001]。与健康受试者相比,疑似LPRD患者的症状对其生活质量的影响评分较高(t=7.15,P<0.001)。所有疑似LPRD患者和健康受试者认为RSS能较好评估其症状。结论RSS量表内在和外在信度良好,校标效度和反应度良好,可作为评估LPRD症状的重要参考指标之一。Objective To produce the Chinese version of a new reflux symptom score(RSS)of laryngopharyngeal reflux disease(LPRD)and to evaluate its reliability,validity and clinical value.Methods This was a retrospective study which contained 42 healthy volunteers and 135 possible LPRD patients.RSI,RFS,oropharyngeal pH monitoring(Dx-pH monitoring)and RSS of each patient were performed.RSS was performed again after 1 week.Confirmed LPRD patients were treated with proton pump inhibitor for 8 week.And RSS was performed again after treatment.Reliability and validity of RSS were evaluated.Results The Cronbach′sαcoefficient of RSS was 0.77,which indicated good internal reliability of the new score.The results of test-retest found all P values were less than 0.05,which supported good external reliability.Comparing RSS with laryngopharyngeal reflux test results,the diagnostic coincidence rate was 84.44%(114/135),and the positive predictive value was 85.71%(114/133),which showed good criterion validity.After 8 weeks treatment of PPI,RSS decreased significantly(pretreatment 84.79±42.50,posttreatment 20.11±22.82,t=-10.54,P<0.001),indicating good reactivity of RSS.The score of quality of life impact(Qol)in possible LPRD patients was obviously higher than that of healthy volunteers(t=7.15,P<0.001).All patients and volunteers believed that RSS was a good way to evaluate their symptoms.Conclusions The new score RSS have good internal and external reliability,criterion validity and reactivity.RSS can be one of the important reference indexes to evaluate LPRD.

关 键 词：咽喉反流性疾病 问卷调查 疾病严重程度指数 可重复性 结果 

分 类 号：R766.5[医药卫生—耳鼻咽喉科]