6%羟乙基淀粉130/0.4对创伤性蛋白微血管渗漏影响的研究进展  

Research progress on anti-inflammatory effect of 6%hydroxyethyl starch 130/0.4 in microvascular leakage of traumatic protein

作　　者：张倩 谢永刚 马加海[2] 张建中[3] ZHANG Qian;XIE Yonggang;MA Jiahai;ZHANG Jianzhong(The 2nd Medical College of Binzhou Medical University,Yantai 264000,China;Department of Anesthesiology,Yuhuangding Hospital,Yantai 264008,China;Department of Anesthesiology,Yantaishan Hospital,Yantai 264008,China)

机构地区：[1]滨州医学院第二临床医学院,山东烟台264000 [2]烟台市毓璜顶医院麻醉科,山东烟台264000 [3]烟台市烟台山医院麻醉科,山东烟台264000

出　　处：《山东第一医科大学（山东省医学科学院）学报》2022年第11期856-859,共4页Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences

基　　金：烟台市科技创新发展计划(2021MSGY048);滨州医学院“临床+X”科技创新项目(BY2021LCX35)。

摘　　要：6%羟乙基淀粉130/0.4(6%hydroxyethyl starch 130/0.4,HES)是第三代羟乙基淀粉,中等分子量,输入体内后能够增加血管内的胶体渗透压,起到扩容作用。患者在严重创伤、感染应激和手术治疗后常出现低蛋白血症,严重影响机体功能,严重时可危及患者生命。传统观点认为以上低蛋白血症是肝脏蛋白合成不足和机体蛋白分解代谢加快导致的,但目前研究认为与微血管蛋白渗漏密切相关。最新研究发现,HES可以减少蛋白的微血管渗漏,其机制与抗炎作用有关。本文从HES在炎症反应、炎性通路的作用,对创伤性蛋白微血管渗漏的影响方面作一综述。6%hydroxyethyl starch 130/0.4(HES),the third generation of hydroxyethyl starch,is a medium molecular weight hydroxyethyl starch,which can increase the colloidal osmotic pressure in the blood vessels after infusion into the body and play a role in capacity expansion.Patients often develop hypoproteinemia after severe trauma,infectious stress,and surgery,which can seriously affect the function of the body,and it can endanger the patient's life in severe cases.The traditional view is that hypoproteinemia is caused by insufficient liver protein synthesis and accelerated protein catabolism in the body,but this is believed in current research to be closely related to microvessel protein leakage.The latest research has found that 6%HES can reduce the microvessel leakage of proteins,and its mechanism is related to anti-inflammatory effects.We review the effects of HES on the leakage of traumatic protein microvessels through inflammatory responses and inflammatory pathways.

关 键 词：羟乙基淀粉 炎症反应 炎性通路 蛋白渗漏 

分 类 号：R641[医药卫生—外科学]