慢性阻塞性肺疾病大鼠模型造模方法研究进展  

Research progress in modeling methods of COPD rat model

作　　者：尚金钰 付延鑫 高胜寒 纪思禹 白亚虎 宁康 SHANG Jinyu;FU Yanxin;GAO Shenghan;JI Siyu;BAI Yahu;NING Kang(Graduate Department,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250017,China;Graduate Department,Weifang Medical University,Weifang 261053,China;Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Shandong First Medical University,Jinan 250014,China)

机构地区：[1]山东第一医科大学(山东省医学科学院)研究生部,山东济南250017 [2]潍坊医学院研究生部,山东潍坊261053 [3]山东第一医科大学第一附属医院呼吸与危重症医学科,山东济南250014

出　　处：《山东第一医科大学（山东省医学科学院）学报》2022年第11期865-869,共5页Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences

基　　金：山东省自然科学基金(ZR202103010567)。

摘　　要：慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是全球慢病导致死亡的重要病因。快速建立稳定表现COPD标志特征的动物模型是进一步探究COPD机制的基础。目前国内外仍未有公认规范的COPD大鼠建模方法,本研究参考近年来应用大鼠制备COPD模型的相关实验文献及综述文献,总结近年大鼠COPD模型常用造模方法,可主要分为单因素制备COPD大鼠模型方法及多因素联合造模方法,以期对规范建立COPD大鼠模型有所助益。Chronic obstructive pulmonary disease(COPD)is an important cause of death caused by chronic diseases worldwide.The rapid establishment of animal models with stable signs of COPD is the basis for further exploration of the disease mechanism of COPD.At present,there is still no recognized and standardized COPD rat modeling method at home and abroad.Referring to the relevant experimental literature and review literature on the application of rats to COPD preparation models in recent years,this paper summarizes the common modeling methods of rat models in recent years,which can be mainly divided into single factor COPD rat model preparation method and multi factor joint modeling method,in order to help standardize the establishment of COPD rat models.

关 键 词：慢性阻塞性肺疾病 大鼠 动物模型 

分 类 号：R563.9[医药卫生—呼吸系统] R-332[医药卫生—内科学]