铁死亡在脑损伤中的研究进展  

Research progress on ferroptosis in brain injury

作　　者：程慧娴 姚芬 操良斌 陈永权 段满林[1] Cheng Huixian;Yao Fen;Cao Liangbin;Chen Yongquan;Duan Manlin(Department of Anesthesiology,Jinling Hospital,the First School of Clinical Medicine,Southern Medical University,Nanjing 210002,China;Department of Anesthesiology,the First Affiliated Hospital(Yijishan Hospital)of Wannan Medical College,Wuhu 241001,China)

机构地区：[1]南方医科大学第一临床学院金陵医院麻醉科,南京210002 [2]皖南医学院第一附属医院(弋矶山医院)麻醉科,芜湖241001

出　　处：《国际麻醉学与复苏杂志》2022年第10期1103-1107,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(81671884);皖南医学院中青年科研基金(WK2019F32)。

摘　　要：铁死亡是近年来发现的一种新型细胞死亡机制,通常在细胞死亡过程中伴有大量铁积累和脂质过氧化作用。铁死亡在脑损伤中起关键作用,铁死亡抑制剂可有效改善铁稳态、脂质代谢、氧化还原稳定、神经元重塑和创伤后功能恢复。文章综述了铁死亡最新分子机制及其进展,重点综述其在脑缺血、脑出血、外伤性脑损伤和其他急性脑损伤中的作用。理解铁死亡的作用,可为进一步了解脑损伤发病机制及寻找新的治疗靶点提供参考。Ferroptosis is a new type of cell death that was discovered in recent years and usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process.Ferroptosis plays a key role in brain injury.Ferroptosis inhibitors can effectively improve iron homeostasis,lipid metabolism,redox stabilization,neuronal remodeling,and functional recovery after trauma.In this review,we summarized the latest molecular mechanisms of ferroptosis and current research on ferroptosis,especially its role in the progression of cerebral ischemia,cerebral hemorrhage,traumatic brain injury and other acute brain injury.These findings will provide evidence for further understanding the pathogenesis of brain injury and searching new targets for the treatment of brain injury.

关 键 词：铁死亡 铁离子 脂质代谢 脑损伤 

分 类 号：R651.15[医药卫生—外科学]