Association between new onset type 1 diabetes and real-world antibiotics and neonicotinoids’exposure-related gut microbiota perturbation  

作　　者：Zhen-Ran Xu Xiao-Xiao Yuan Rui-Min Chen Hai-Yan Wei Lin-Qi Chen Hong-Wei Du Gui-Mei Li Yu Yang Xiao-Juan Chen Xin Fang Fei-Hong Luo 

机构地区：[1]Department of Pediatric Endocrinology and Inherited Metabolic Diseases,National Children’s Medical Center,Children’s Hospital of Fudan University,399 Wan Yuan Road,Shanghai,201102,China [2]Fuzhou Children’s Hospitai of Fujian Medical University,Fuzhou,China [3]Department of Endocrinology and Inherited Metabolic,Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou,China [4]Children’s Hospital of Soochow University,Suzhou,China [5]The First Hospital of Jilin University,Changchun,Jilin,China [6]Department of Pediatric Endocrinology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,China [7]The Affiliated Children’s Hospital of Nanchang University,Nanchang,China [8]Department of Endocrinology,Genetics and Metabolism,The Children’s Hospital of Shanxi Province,Taiyuan,China [9]Fujian Medical University Union Hospital,Fuzhou,China

出　　处：《World Journal of Pediatrics》2022年第10期671-679,共9页世界儿科杂志（英文版）

基　　金：supported by the National Key Research and Development Program of China(2016YFC1305302);the Clinical special project of integrated traditional Chinese and Western medicine in 2019,Shanghai Municipal Health Commission,Shanghai Municipal Administrator of Traditional Chinese Medicine.

摘　　要：Background The real-world exposure levels of non-therapeutic antibiotics and neonicotinoids in type 1 diabetes(T1D)children and their associations as environmental triggers through gut microbiota shifts remained unknown.We thus investigated the antibiotics and neonicotinoids’exposure levels and their associations with gut microbiota in pediatric T1D.Methods Fifty-one newly onset T1D children along with 67 age-matched healthy controls were recruited.Urine concentrations of 28 antibiotics and 12 neonicotinoids were measured by mass spectrometry.Children were grouped according to the kinds of antibiotics’and neonicotinoids’exposures,respectively.The 16S rRNA of fecal gut microbiota was sequenced,and the correlation with urine antibiotics and neonicotinoids’concentrations was analyzed.Results The overall detection rates of antibiotics were 72.5%and 61.2%among T1D and healthy children,whereas the neonicotinoids detection rates were 70.6%and 52.2%(P=0.044).Children exposed to one kind of antibiotic or two or more kinds of neonicotinoids had higher risk of T1D,with the odd ratios of 2.579 and 3.911.Furthermore,co-exposure to antibiotics and neonicotinoids was associated with T1D,with the odd ratio of 4.924.Antibiotics or neonicotinoids exposure did not affect overall richness and diversity of gut microbiota.However,children who were exposed to neither antibiotics nor neonicotinoids had higher abundance of Lachnospiraceae than children who were exposed to antibiotics and neonicotinoids alone or together.Conclusion High antibiotics and neonicotinoids exposures were found in T1D children,and they were associated with changes in gut microbiota featured with lower abundance of butyrate-producing genera,which might increase the risk of T1D.

关 键 词：ANTIBIOTICS Gut microbiota NEONICOTINOIDS Type 1 diabetes mellitus 

分 类 号：R725.8[医药卫生—儿科]