光催化去消旋化的研究进展  

Recent Advances in Photocatalytic Deracemization

作　　者：苏艺雯 邹有全 肖文精[3] Su Yiwen;Zou Youquan;Xiao Wenjing(School of Pharmaceutical Sciences,Wuhan University,Wuhan 430071;TaiKang Center for Life and Medical Sciences,Wuhan University,Wuhan 430071;College of Chemistry,Central China Normal University,Wuhan 430079)

机构地区：[1]武汉大学药学院,武汉430071 [2]武汉大学泰康生命医学中心,武汉430071 [3]华中师范大学化学学院,武汉430079

出　　处：《有机化学》2022年第10期3201-3212,共12页Chinese Journal of Organic Chemistry

基　　金：武汉大学人才启动基金(Nos.691000002,600460026);国家自然科学基金(Nos.21820102003,91956201)资助项目。

摘　　要：手性广泛存在于众多天然产物和药物分子中,由于对映体之间具有不同甚至是相反的生理活性,获得光学纯的手性化合物具有重要的研究意义.去消旋化是获得单一对映体最直接、最有效和最原子经济的途径,而新兴的光催化去消旋化由于其高效性更是备受瞩目.综述了光催化去消旋化最新的研究进展,并对该领域未来的研究前景进行了展望.Chirality is widely found in many natural products and drug molecules. It is of great significance to obtain optically pure chiral compounds because of the fact that different enantiomers have distinct or even opposite physiological activities.Deracemization is the most direct, efficient and atom-economic approach to obtain a single enantiomer, and the emerging photocatalytic deracemization attracts much attention because of its high efficiency. Herein, the recent advances in photocatalytic deracemization are summarized. The future research direction of this field is also prospected.

关 键 词：去消旋化 手性分子 不对称合成 光催化 

分 类 号：O621.251[理学—有机化学]