金属卡宾参与的对映选择性去对称化反应研究进展  

Research Progress on Enantioselective Desymmetrization Reactions Involving Metal Carbenes

作　　者：滕明瑜[1] 韩涛 黄恩和 叶龙武 Teng Ming-Yu;Han Tao;Huang En-He;Ye Long-Wu(College of Chemistry and Chemical Engineering,Yunan Normal University,Kunming 650500;College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032)

机构地区：[1]云南师范大学化学化工学院,昆明650500 [2]厦门大学化学化工学院,厦门361005 [3]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海200032

出　　处：《有机化学》2022年第10期3295-3301,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.92056104)资助项目。

摘　　要：金属卡宾在有机合成中具有非常重要的应用,其不同的活性可以发生形式多样的化学反应.以金属卡宾的反应类型分类,介绍了金属卡宾参与的去对称化C—H插入反应、Buchner反应、Si—H插入反应和B—H插入反应.在手性铑、钌、铜等催化剂的催化下,反应可高对映选择性地合成手性碳环化合物、杂环化合物、有机硅化合物和有机硼化合物,极大地丰富了不对称合成化学的发展.Metal carbenes have been widely applied in organic synthesis,and they can undergo a variety of chemical transformations due to their versatile reactivities.In this review,the desymmetrization of C—H insertion reaction,Buchner reaction,Si—H insertion reaction and B—H insertion reaction involving metal carbenes is introduced according to the different reaction types of metal carbenes.Under the catalysis of chiral rhodium,ruthenium and copper catalysts,chiral carbocycles,heterocycles,organosilicons and organoborons can be obtained with high enantioselectivity,which greatly enriches the development of asymmetric synthetic chemistry.

关 键 词：重氮化合物 金属卡宾 去对称化 不对称合成 

分 类 号：O621.251[理学—有机化学]