手性Lewis酸催化的可见光不对称合成研究进展  

Recent Advances in Visible-Light Photocatalytic Asymmetric Synthesis Enabled by Chiral Lewis Acids

作　　者：成秀亮 李冬 杨博轩 林玉妹 龚磊[1,2] Cheng Xiuliang;Li Dong;Yang Boxuan;Lin Yumei;Gong Lei(College of Chemistry and Chemical Engineering,Key Laboratory of Chemical Biology of Fujian Province,Xiamen University,Xiamen,Fujian 361005;Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM),Xiamen,Fujian 361005)

机构地区：[1]厦门大学化学化工学院,福建省化学生物学重点实验室,福建厦门361005 [2]福建省能源材料科学与技术创新实验室(IKKEM),福建厦门361005

出　　处：《有机化学》2022年第10期3335-3350,共16页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.22071209,22071206);国家高层次青年人才资助项目。

摘　　要：近年来,可见光催化不对称合成已在快速构筑结构多样的光活性有机分子上展现了相当的潜力.手性Lewis酸(CLA),如手性硼烷化合物、镧系配合物、第一过渡系金属配合物、金属中心手性铱及铑配合物等,能有效控制可见光驱动自由基反应过程的立体化学.按照手性Lewis酸双功能催化和手性Lewis酸/可见光催化剂协同催化这两种主要反应类型,简要介绍了这一领域的最新进展,以期促进有机合成、光催化、不对称催化领域的发展.In recent years,visible-light photocatalytic asymmetric synthesis has shown considerable potential in the mild and rapid construction of optically active organic molecules with structural diversity.Chiral Lewis acids(CLA),including chiral borane compounds,lanthanum complexes,first-row transition metal complexes,and chiral-at-iridium or rhodium complexes,have been established as one class of the most effective catalysts being capable of controlling the stereochemistry in photo-induced chemical transformations.The recent advances in this emerging field were presented by classifying the reactions into bifunctional CLA photocatalytic reactions and reactions enabled by dual catalysis with a CLA catalyst and an external photosensitizer,expecting that these studies will stimulate progress in organic synthesis,photocatalysis and asymmetric catalysis.

关 键 词：可见光催化 不对称合成 手性Lewis酸 协同催化 双功能催化 

分 类 号：O621.251[理学—有机化学]