钯/新型轴手性膦-烯配体催化的吲哚不对称烯丙基烷基化反应  

Pd/Novel Axially Chiral Phosphine-Alkene Ligands Catalyzed Asymmetric Allylic Alkylation of Indoles

作　　者：贾仕虎 陈思元 刘泽水 程鸿刚 周强辉 Jia Shihu;Chen Siyuan;Liu Zeshui;Cheng Honggang;Zhou Qianghui(College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072;Green Catalysis Center,College of Chemistry,Zhengzhou University,Zhengzhou 450001;The Institute for Advanced Studies,Wuhan University,Wuhan 430072)

机构地区：[1]武汉大学化学与分子科学学院,武汉430072 [2]郑州大学化学学院,绿色催化中心,郑州450001 [3]武汉大学高等研究院,武汉430072

出　　处：《有机化学》2022年第10期3373-3381,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21871213,22071189);中央大学基础研究基金(No.2042021kf0214)资助项目。

摘　　要：基于两步模块化合成,制备了一类新型的联芳基轴手性膦-烯配体.该类配体在钯催化的吲哚不对称烯丙基烷基化反应中表现出很好的催化活性和不对称诱导效果.在最优的反应条件下,能以高达95%的收率和96%的对映选择性生成一系列手性的烯丙基吲哚化合物.A new type of axially chiral phosphine-alkene ligands have been developed via a two-step modular synthesis for Pd-catalyzed asymmetric allylic alkylation of indoles. Under optimized reaction conditions, a series of chiral allylindole products were obtained in generally high yields(up to 95%) and excellent enantioselectivities(up to 96% ee).

关 键 词：钯催化 膦-烯配体 吲哚 烯丙基烷基化 不对称催化 

分 类 号：O626[理学—有机化学]