耳部感染患者病原菌分布及药敏分析  

Distribution and drug sensitivity analysis of pathogenic bacteria in patients with ear infection

作　　者：褚连军[1] 童明琼 孙婉 CHU Lian-jun;TONG Ming-qiong;SUN Wan(Dezhou University,Dezhou 253023,Shandong,China)

机构地区：[1]德州学院,山东德州253023

出　　处：《中国病原生物学杂志》2022年第10期1180-1183,共4页Journal of Pathogen Biology

摘　　要：目的 通过分析耳部感染患者的病原菌分布情况及药敏分析结果,研究本地区耳部感染患者的病原学特征。方法 收集2020年3月至2021年12月耳科接诊的168例耳部感染患者病例资料,采集耳部脓性分泌物,进行细菌培养、鉴定及药敏试验,比较分析慢性化脓性中耳炎患者与外耳道炎患者的病原菌培养结果,对比慢性化脓性中耳炎活动期与静止期患者的手术方式。结果 168例耳部感染患者中,56.55%为慢性化脓性中耳炎,34.52%为外耳道炎。主要症状为听力下降(86.91%)与耳部流脓(72.62%)。共收集到191例脓性分泌物标本,其中145例病原菌培养阳性,包括革兰阳性菌62株,革兰阴性菌40株,真菌43株。主要为金黄色葡萄球菌(28.28%),铜绿假单胞菌(17.93%),黑曲霉(18.62%)。对比慢性化脓性中耳炎患者与外耳道炎患者的病原菌培养结果,两组的病原菌培养阳性率、铜绿假单胞菌检出率,差异无统计学意义,两组的金黄色葡萄球菌、黑曲霉检出率差异有统计学意义。金黄色葡萄球菌对青霉素、红霉素的耐药率分别为90.24%、80.49%,对万古霉素、利奈唑胺的敏感性均为100.00%。铜绿假单胞菌对头孢他啶、头孢吡肟、环丙沙星、复方新诺明和庆大霉素的耐药率分别为19.23%、11.54、19.23%、30.77%和30.77%,对亚胺培南、阿米卡星的敏感性均为100.00%。黑曲霉对两性霉素B、制菌霉素的耐药率分别为51.85%、33.33%,对伊曲康唑的敏感性为100.00%。慢性化脓性中耳炎患者中,58.95%活动期,41.05%为静止期。慢性化脓性中耳炎活动期患者中,62.50%行开放式乳突切开+鼓室成形术。慢性化脓性中耳炎静止期患者中,58.97%行完璧式乳突切开+鼓室成形术。对比两组手术方式,在进行开放式乳突切开+鼓室成形术、完璧式乳突切开+鼓室成形术差异有统计学意义,在进行鼓室成形术无差异。结论 耳部感染患者主要为慢性化脓性中耳炎�Objective By analyzing the distribution of pathogenic bacteria and the results of drug sensitivity analysis in patients with ear infection, the pathogenic characteristics of patients with ear infection in this region were studied. Methods The data of 168 patients with ear infection admitted by the otology Department of our hospital from March 2020 to December 2021 were collected, and the ear purulent secretions were collected for bacterial culture, identification and drug sensitivity test. The results of pathogen culture between patients with chronic suppurative otitis media and patients with external auditory meatus were compared and analyzed, and the surgical Methods of patients with chronic suppurative otitis media in active and static stages were compared. Results Among 168 patients with ear infection, 56.55% were chronic suppurative otitis media and 34.52% were external otitis media. The main symptoms were hearing loss(86.91%) and ear pus(72.62%). A total of 191 specimens of purulent secretions were collected, of which 145 were positive for pathogen culture, including 62 strains of Gram-positive bacteria, 40 strains of Gram-negative bacteria and 43 strains of fungi. Mainly Staphylococcus aureus(28.28%),Pseudomonas aeruginosa(17.93%),Aspergillus niger(18.62%). Comparing the results of pathogen culture between patients with chronic suppurative otitis media and patients with otitis externa, there was no significant difference in the positive rate of pathogen culture and the detection rate of P. aeruginosa between the two groups, and there was significant difference in the detection rates of Staphylococcus aureus and A. niger between the two groups. The resistance rates of Staphylococcus aureus to penicillin and erythromycin were 90.24% and 80.49% respectively, and the sensitivity to vancomycin and linezolid was 100.00%. The resistance rates of P. aeruginosa to ceftazidime, cefepime, ciprofloxacin, cotrimoxazole and gentamicin were 19.23%,11.54%,19.23%,30.77% and 30.77% respectively, and the sensitivity to imipe

关 键 词：耳部感染 慢性化脓性中耳炎 外耳道炎 病原菌 手术方式 

分 类 号：R378[医药卫生—病原生物学]