疟疾传播阻断疫苗的研究进展  

Progress of research on malaria transmission blocking vaccines

作　　者：王姗姗 赵龙玉 全芯 薛庆节 谭文彬 李士根 杜峰 WANG Shan-shan;ZHAO Long-yu;Quan Xin;XUE Qing-jie;TAN Wen-bin;LI Shi-gen;DU Feng(Department of Pathology,Institute of Precise on Medicine,Jining Medical University,Jining,Shandong 272067,China;Department of Pathogenic Biology,Jining Medical University)

机构地区：[1]济宁医学院精准医学研究院,山东济宁272067 [2]济宁医学院基础医学院病原生物学教研室

出　　处：《中国病原生物学杂志》2022年第10期1229-1236,共8页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.82101867);济宁医学院贺林院士新医学临床转化工作站科研基金项目(No.JYHL2018MS18);济宁医学院青年教师科研扶持基金项目(No.JYFC2018KJ030)。

摘　　要：疟疾是经按蚊叮咬或输入带疟原虫者的血液而感染疟原虫所引起的虫媒传染病。蚊虫易被疟原虫感染并传播病原体是消除疟疾面临的一个巨大挑战。疟疾传播阻断疫苗旨在阻断疟原虫在蚊体内的生活史过程,免除蚊的感染,从而阻止疟疾传播。与其他防控策略联合使用,有望促进流行区疟疾的消除乃至根除。本文综述了疟疾传播阻断疫苗的研究进展,并对传播阻断免疫进行概述,以期为疟疾传播阻断疫苗的研制提供理论参考。Malaria is the deadliest insect-borne disease caused by Plasmodium parasites,which are spread to people through the bites of infected female Anopheles mosquitoes.The efficient spread of malaria from infected humans to mosquitoes is a major challenge for malaria elimination initiatives.Malaria transmission blocking vaccines(TBVs)target Plasmodium stages that transmit between human and mosquitos in order to interrupt the parasite’s life cycle and reduce spread.Combined with other prevention and control strategies,TBVs could contribute to malaria elimination from affected communities and malaria eradication worldwide.This article reviews the recent developments in TBVs and the transmission-blocking immunity in order to provide a theoretical reference to the development of TBVs.

关 键 词：疟疾 传播阻断疫苗 配子体 免疫 综述 

分 类 号：R531.3[医药卫生—内科学]