肠道益生菌联合间歇性蓝光照射治疗新生儿高胆红素血症效果  

Effect of Probiotics Combined with Intermittent Blue Light Irradiation on Neonatal Hyperbilirubinemia

作　　者：林坤万 LIN Kunwan(Zhangpu County Maternal and Child Health Hospital,Zhangzhou 363200,China)

机构地区：[1]漳浦县妇幼保健院,福建漳州363200

出　　处：《中国医药指南》2022年第36期104-106,共3页Guide of China Medicine

摘　　要：目的 探究肠道益生菌联合间歇性蓝光照射在治疗新生儿高胆红素血症中的效果,分析该疗法的有效性和可行性,为新生儿高胆红素血症治疗提供新思路和研究方向。方法 选取2020年6月至2022年5月期间我院收治的新生儿高胆红素血症116例患儿作为本次研究对象。将所有研究对象进行随机均等分组,每组分别有研究对象58例。对所有研究对象在入院后均给予包括常规药物治疗、营养补充以及指标检测等,在此基础上给予对照组间歇性蓝光照射治疗,对观察组患儿给予肠道益生菌联合间歇性蓝光照射治疗。观察对比两组患儿治疗后C反应蛋白(CRP)及肝功能等指标变化情况,比较治疗后两组研究对象疗效、治疗时长以及体内胆红素情况,记录两组患儿不良反应发生率。结果 治疗后两组患儿肝功能及CRP指标有所改善,观察组改善情况较对照组更为显著,差异比较均具有统计学意义(P <0.05);治疗前所有研究对象胆红素总体情况具有可比性,治疗后观察组患儿胆红素水平较对照组更为正常,情况改善差异具有统计学意义(P <0.05);观察组整体疗效好于对照组,且不良反应较对照组更少,差异均具有统计学意义(P <0.05)。结论 肠道益生菌联合间歇性蓝光照射治疗新生儿高胆红素血症的实际效果值得肯定,在患儿治疗中效果确切,促进患儿胆红素水平下降,有效改善患儿肝功能,且不良反应发生率较低,临床疗效可靠,有效促进患儿整体康复,值得临床推广应用。Objective To explore the effect of intestinal probiotics combined with intermittent blue light irradiation in the treatment of neonatal hyperbilirubinemia,analyze the effectiveness and feasibility of the therapy,and provide new ideas and research direction for the treatment of neonatal hyperbilirubinemia.Methods A total of 116 children with neonatal hyperbilirubinemia admitted to our hospital from June 2020 to May 2022 were selected as the research objects.All subjects were randomly divided into equal groups,with 58 subjects in each group.After admission,all the subjects were given conventional drug treatment,nutritional supplementation and index detection.On this basis,the control group was given intermittent blue light irradiation,and the observation group was given intestinal probiotics combined with intermittent blue light irradiation.The changes of C-reactive protein(CRP) and liver function were observed and compared between the two groups after treatment.The efficacy,duration of treatment and bilirubin in the two groups after treatment were compared.The incidence of adverse reactions in the two groups was recorded.Results After treatment,the liver function and CRP indexes of the two groups were improved,and the improvement of the observation group was more significant than that of the control group,and the differences were statistically significant(P<0.05).Before treatment,the overall bilirubin level of all the subjects was comparable.After treatment,the bilirubin level of the observation group was more normal than that of the control group,and the improvement difference was statistically significant(P<0.05).The overall efficacy of the observation group was better than that of the control group,and the adverse reactions were less than that of the control group,the differences were statistically significant(P<0.05).Conclusion The intestinal probiotics combined intermittent high blue light treatment of neonatal bilirubin levels,the actual effect is positive,in children with treatment effect is exact,promote c

关 键 词：肠道益生菌 间歇性蓝光照射 新生儿 高胆红素血症 

分 类 号：R722.1[医药卫生—儿科]