心脏纤维化中力学信号转导的研究进展  

Research progress of mechanotransduction in cardiac fibrosis

作　　者：施雯 陈亨 陈宇潇 杨剑 郭晓纲[1] SHI Wen;CHEN Heng;CHEN Yuxiao;YANG Jian;GUO Xiaogang(Department of Cardiology,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310003,China)

机构地区：[1]浙江大学医学院附属第一医院心血管内科,浙江省杭州市310003

出　　处：《中国动脉硬化杂志》2023年第1期24-33,共10页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金区域创新发展联合基金(U21A20337);国家自然科学基金面上项目(82170331)。

摘　　要：心脏纤维化会引发心脏舒张和收缩障碍,诱发心律失常,增加心血管疾病患者的再入院率和死亡风险。成纤维细胞是维持和促进心脏组织细胞外基质沉积的主要细胞类型,并且对力学微环境改变敏感。最近的研究揭示了力学因素影响成纤维细胞功能的具体力学信号转导通路。文章对此进行了综述,并就体外力学模型和临床研究进展进行了适当讨论。Cardiac fibrosis can cause cardiac diastolic and systolic disorders,induce arrhythmias,and increase the risk of hospital readmission and death in patients with cardiovascular disease.Fibroblasts are the main cell type that maintains and promotes extracellular matrix deposition in cardiac tissue and are sensitive to changes in the mechanical microenvironment.Recent studies have revealed the specific mechanical signal transduction pathways through which mechanical factors influence fibroblast function.In this review,mechanotransduction,vitro mechanical models and clinical advances are discussed.

关 键 词：心脏纤维化 力学信号转导 成纤维细胞 整合素 

分 类 号：R5[医药卫生—内科学]