富含Gla蛋白参与冠状动脉钙化机制的研究进展  

Research progress on the mechanism of Gla-rich protein involvement in coronary artery calcification

作　　者：程增为 胡司淦[1] CHENG Zengwei;HU Sigan(Department of Cardiology,the First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院心血管内科,安徽省蚌埠市233004

出　　处：《中国动脉硬化杂志》2023年第1期88-92,共5页Chinese Journal of Arteriosclerosis

基　　金：安徽省高校自然科学研究重点项目(KJ2021A0818)。

摘　　要：冠状动脉钙化在冠状动脉粥样硬化性心脏病患者中较为常见,目前对其发生、发展及形成机制尚不清楚。富含Gla蛋白(GRP)是新近发现的维生素K依赖性蛋白,研究表明GRP通过与矿物质结合发挥抑制钙化晶体的形成及成熟、参与基质Gla蛋白-胎球蛋白A钙化的抑制途径、阻断钙化诱导剂的信号通路及抗炎作用,起到抑制血管钙化的作用。本文就GRP参与冠状动脉钙化机制的研究进展进行综述,为冠状动脉钙化的预防、治疗提供新的方向。Coronary artery calcification is commonly seen in patients with coronary atherosclerotic heart disease, but the mechanism of its happening, development, and formation is less known. Gla-rich protein(GRP) is a newly discovered vitamin K-dependent protein. Studies have shown that GRP inhibits the formation and maturation of calcified crystals by binding to minerals, participates in the inhibition pathway of matrix Gla protein-fetuin-A calcification, blocks the signalling pathway of calcification inducers and has an anti-inflammatory effect, thus playing a role in inhibiting vascular calcification. In this paper, the research progress of GRP’s participation in the mechanism of coronary artery calcification will be conducted in the hope of providing a new direction for the prevention and treatment of coronary artery calcification.

关 键 词：冠状动脉钙化 维生素K依赖性蛋白 富含Gla蛋白 

分 类 号：R5[医药卫生—内科学]