嘌呤能系统在高血压病中的作用及机制研究进展  

Advances on the role and mechanism of purinergic system in hypertension

作　　者：王新新 李璐[2] 武广义[2] WANG Xin-xin;LI Lu;WU Guang-yi(School of Clinical Medicine,Hebei University,Baoding 071000,China;Department of Anesthesiology,Affiliated Hospital of Hebei University,Baoding 071000,China)

机构地区：[1]河北大学临床医学院,河北省保定市071000 [2]河北大学附属医院麻醉科

出　　处：《中国心血管病研究》2022年第12期1135-1141,共7页Chinese Journal of Cardiovascular Research

基　　金：河北省医学科学研究课题计划项目(项目编号:20211165);保定市科技计划项目(项目编号:2041ZF326)。

摘　　要：在全球所有心血管疾病中,高血压病是发病率和死亡率的主要原因。现已有研究发现高血压病与嘌呤能系统关系密切,其作用机制复杂。嘌呤能系统可通过交感神经、脑干神经元、颈动脉体、血管内皮细胞、免疫系统、肾素-血管紧张素系统、钠排泄和肾脏自身调节等多种途径在高血压发生过程中发挥重要作用。提示了嘌呤能化合物具有治疗高血压病的作用。Hypertension is the leading cause of morbidity and mortality globally among all the cardiovascular diseases.Although there have been studies that show hypertension is closely related to purinergic system,the mechanism of action was complex.Purinergic system plays a crucial role in hypertension through the sympathetic nerve system,neurons in the brain stem,carotid body,endothelium,immune system,renin-angiotensin system,sodium excretionand renal autoregulation.This review summarizes the relationship between hypertension andpurinergic system,and the impaction of purinergic system on normal blood pressure and hypertension.Thesewould provide the novel perspective to analyze the mechanism of purinergic system on hypertension,and toprovide the potential targets for the treatment of hypertension.

关 键 词：嘌呤能系统 高血压 嘌呤能受体 信号转导 

分 类 号：R544.1[医药卫生—心血管疾病]