基于纳米金的腺嘌呤核苷三磷酸检测体系的研究进展  

Gold Nanoparticles-Based Sensor for ATP Detection

作　　者：周鸿 鲁琴芮 李毅[1] 周春阳[1] 罗荧萍 Zhou Hong;Lu Qinrui;Li Yi;Zhou Chunyang;Luo Yingping(North Sichuan Medical College,Nanchong,637000)

机构地区：[1]川北医学院,南充637000

出　　处：《化学通报》2022年第11期1304-1311,1296,共9页Chemistry

基　　金：2021年中央引导地方科技发展资金面上项目(2021ZYD0051);川北医学院博士科研启动项目(CBY19-QD03);2020川北医学院药学一流学科群建设项目(CBY20-YLXK03)资助。

摘　　要：腺嘌呤核苷三磷酸(ATP)是机体代谢过程中不可或缺的能量物质,参与机体的各项重要的生理生化活动,在各方面起着至关重要的作用。因此,对ATP的快速精准检测具有重要的临床意义。纳米金(AuNPs)因优良的光学特性、催化活性、生物相容性等特点,被广泛应用于构建ATP检测体系。本文综述了目前AuNPs应用于ATP检测(如比色、荧光分析、电化学、电化学发光、化学发光以及表面增强拉曼散射等)的研究进展,比较了各种检测方法的优点与不足,并对AuNPs在ATP检测应用中面临的挑战和机遇作了展望。Adenosine Triphosphate(ATP) is an indispensable energy substance in the body’s metabolic process. It participates in various important physiological and biochemical activities and plays a vital role in various aspects. Therefore, the rapid and accurate detection of ATP has important clinical significance. Gold nanoparticles(AuNPs) are widely used to construct ATP detection sensors due to their excellent optical properties, catalytic activity, and biocompatibility. In this paper, advantages and deficiencies of ATP sensors based on AuNPs, such as colorimetric, fluorescence, electrochemical, chemiluminescence, electrochemiluminescence and surface-enhanced Raman scattering analysis, were summarized. Mover, the challenges and opportunities faced by AuNPs in the application of ATP detection are also prospected.

关 键 词：腺嘌呤核苷三磷酸 纳米金 检测探针 

分 类 号：Q503[生物学—生物化学] O657.3[理学—分析化学]