水体中痕量四环素类抗生素分析方法研究进展  

Advances in Analytical Methods for Trace Tetracycline Antibiotics in Water

作　　者：马江雄 周欣[1] 赵超[1] 陈华国[1] 龚小见[1] Ma Jiangxiong;Zhou Xin;Zhao Chao;Chen Huaguo;Gong Xiaojian(Guizhou Key Laboratory of Mountain Environment Information System and Ecological Environment Protection,Collaborative Innovation Center of Karst Mountain Ecological Environment Protection and Resource Utilization,Guizhou Provincial Laboratory of Drug Quality Control and Evaluation Technology,Natural Medicine Quality Control Research Center,Guizhou Normal University,Guiyang,550001)

机构地区：[1]贵州师范大学贵州省山地环境信息系统与生态环境保护重点实验室,喀斯特山地生态环境保护与资源利用协同创新中心,贵州省药物质量控制及评价技术工程实验室,天然药物质量控制研究中心,贵阳550001

出　　处：《化学通报》2022年第11期1336-1345,共10页Chemistry

基　　金：贵州省高层次创新人才培养项目(黔科合人才(2015)4033号);贵州师范大学2018年度学术新苗培养及创新探索专项项目(黔科合平台人才[2018]5769-27)资助。

摘　　要：四环素类(TCs)抗生素在水体中具有较长的半衰期,常以微量形式在水中积累,通过饮用水和食物链进入哺乳动物体内,引发肝脏损伤、增加耐药性、威胁环境安全。因此,使用灵敏度高和选择性强的分析方法检测水体TCs抗生素,了解和规避潜在的环境风险极为重要。本文综述了水体TCs抗生素常用预处理方法和检测技术,磁性固相萃取和传统固相萃取是目前使用较多且效果较好的两种萃取技术,液相色谱-紫外检测与液相色谱-质谱联用技术是使用最广泛的两种常规分析技术。此外,近几年发展的传感技术有望取代操作要求高和仪器昂贵的色谱分析技术,尤其是在实时、快速和便携式分析方面具有较好的应用前景。Tetracyclines(TCs) antibiotics have a long half-life in water bodies and often accumulate in water in trace amounts, entering mammals through drinking water and the food chain, causing liver damage, increasing resistance, and threatening environmental safety. Therefore, it is extremely important to use a sensitive and selective analytical method to detect TCs antibiotics in water to understand and avoid potential environmental risks. In this paper, the common pretreatment methods and detection techniques for aqueous TCs antibiotics are reviewed. Magnetic solid-phase extraction and conventional solid-phase extraction are the two extraction techniques that are more frequently used and more effective, and liquid chromatography-UV detection and liquid chromatography-mass spectrometry(LC-MS) are the two most widely used conventional analytical techniques. In addition, sensing techniques developed in recent years are expected to replace chromatographic analysis techniques with high operational requirements and expensive instruments. They have good application prospects in real-time, rapid and portable analysis.

关 键 词：四环素类抗生素 固相萃取 色谱法 传感器 

分 类 号：X832[环境科学与工程—环境工程] O657[理学—分析化学]