葛根素抗器官纤维化作用机制的研究进展  

Research progress on the mechanism of puerarin against organ fibrosis

作　　者：张璋 陈卫民 毛舜 谢赛飞 谢辉[1,2] 郭锦材 ZHANG Zhang;CHEN Weimin;MAO Shun;XIE Saifei;XIE Hui;GUO Jincai(Hunan University of Chinese Medicine,Changsha,Hunan 410208,China;Changsha Stomatological Hospital,Changsha,Hunan 410006,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]长沙市口腔医院,湖南长沙410006

出　　处：《湖南中医药大学学报》2022年第12期2128-2133,共6页Journal of Hunan University of Chinese Medicine

基　　金：湖南省临床医疗技术创新引导项目(2020SK53206);湖南省自然科学基金项目(2021JJ70062);湖南中医药大学校院联合基金项目(2022XYLH120,2022XYLH134);湖南省保健专项资金科研课题(B2020-07);湖南省医学会临床药学科研基金项目(HMA202001012);湖南省卫生健康委员会科研计划项目(D202313048136);长沙市自然科学基金项目(kq2014019)。

摘　　要：器官纤维化是机体在多种刺激因子作用下,成纤维细胞增殖或表型转化,胶原蛋白表达增强,继而引起细胞外基质过度沉积,最终可导致器官衰竭。目前,尚无抗纤维化特异性治疗方法,寻找一种高效低毒抗纤维化药物一直是临床迫切需求。研究发现,葛根素有抗心脏、肝、肺、肾、子宫等器官纤维化作用,其作用机制与抗炎、调节氧化应激及阻断胶原纤维异常沉积等有关。对葛根素抗器官纤维化的分子机制研究进展进行阐述,为进一步明确葛根素抗纤维化作用机制及临床应用提供参考。Organ fibrosis is the proliferation or phenotypic transformation of fibroblasts in the body induced by various stimulating factors,and the enhancement of collagen expression,which leads to excessive deposition of extracellular matrix and ultimately leads to organ failure.Since there is currently no specific therapeutic method of anti-fibrosis,looking for a high-efficiency,low-toxicity and anti-fibrosis drug has been the urgent clinical needs.Studies have found that puerarin has an anti-fibrosis effect on the heart,liver,lung,kidney,uterus and other organs,and its mechanism is related to anti-inflammation,regulating oxidative stress and blocking abnormal deposition of collagen fibers.This review mainly expounds the research progress of the molecular mechanism of puerarin against organ fibrosis,and provides reference for further clarifying the mechanism of puerarin against fibrosis and its clinical application.

关 键 词：葛根素 纤维化 作用机制 信号通路 抗炎 抗氧化应激 

分 类 号：R276.8[医药卫生—中医五官科学]