异甘草酸镁治疗慢性肝炎高转氨酶血症的临床效果分析  

Clinical Effect Analysis of Magnesium Isoglycyrrhizinate in Treatment of Chronic Hepatitis with High Aminotransfer⁃ase

作　　者：张婉茹 吴姗珊 叶颖 Zhang Wan-ru;Wu Shan-shan;Ye Ying(Department of Internal Medicine,Dongguan Hengli Hospital,Dongguan 523460,Guangdong Province,China;Functional Department,Dongguan Hengli Hospital,Dongguan 523460,Guangdong Province,China)

机构地区：[1]东莞市横沥医院内科,广东东莞523460 [2]东莞市横沥医院功能科,广东东莞523460

出　　处：《中外医药研究》2022年第6期63-65,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:观察异甘草酸镁治疗慢性肝炎高转氨酶血症的临床效果。方法:选取2016年1月-2021年12月东莞市横沥医院收治的慢性肝炎高转氨酶血症患者60例,使用随机数字表法将其分为观察组和对照组,各30例。对照组给予常规治疗,观察组在对照组基础上联合异甘草酸镁治疗。比较两组患者肝纤维化指标、肝功能、临床疗效和不良反应发生率。结果:治疗后,两组患者血清Ⅲ型前胶原、血清层粘连蛋白、血清透明质酸水平均下降,观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组患者谷草转氨酶、丙氨酸氨基转移酶、总胆红素水平均下降,观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:异甘草酸镁治疗慢性肝炎高转氨酶血症患者可起到改善肝功能、延缓肝纤维化进程、提高临床疗效的作用,且安全性较高。Objective:To observe the clinical effect of magnesium isoglycyrrhizinate in treatment of chronic hepatitis patients with high aminotransferase.Methods:A total of 60 patients with chronic hepatitis and high aminotransferase who were admitted to Dongguan Hengli Hospital from January 2016 to December 2021 were selected.They were divided into control group and observation group according to random number table method,with 30 cases in each group.The control group was given conventional treatment and the observation group was given magnesium isoglycyrrhizinate treatment on the basis of control group.The liver fibrosis index,liver function,clinical efficacy and incidence of adverse reactions in two groups were compared.Results:After treatment,the levels of serum procollagenⅢ,serum laminin and serum hyaluronic acid decreased in the two groups,and the levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of aspartate aminotransferase,alanine aminotransferase and total bilirubin decreased in the two groups,and the levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Magnesium isoglycyrrhizinate can improve liver function,delay the process of liver fibrosis and improve clinical efficacy in the treatment of chronic hepatitis patients with high aminotransferase,and has high safety.

关 键 词：慢性肝炎 高转氨酶血症 异甘草酸镁 肝纤维化 肝功能 

分 类 号：R28[医药卫生—中药学]