可可碱注射液治疗缺血性心脏病的临床疗效  

Clinical Efficacy of Theobromine Injection in Treatment of Ischemic Heart Disease

作　　者：钟永华 王毅方 Zhong Yong-hua;Wang Yi-fang(First Department of Internal Medicine,Dongguan Hengli Hospital,Dongguan 523460,Guangdong Province,China)

机构地区：[1]东莞市横沥医院内一科,广东东莞523460

出　　处：《中外医药研究》2022年第6期69-71,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探索缺血性心脏病患者应用可可碱注射液治疗的临床疗效。方法:选取2021年1月-2022年7月东莞市横沥医院内一科收治的缺血性心脏病患者74例为观察对象,以盲抽签方式将患者分为对照组与观察组,各37例。对照组给予常规治疗,观察组在对照组基础上联合可可碱注射液治疗,观察两组患者左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左室射血分数(LVEF)、颈动脉内膜中层厚度(IMT),6 min步行距离(6 MWT),基质金属蛋白酶9(MMP-9)、同型半胱氨酸(Hcy)、五聚素3(PTX-3)、内脂素(Visfatin)、治疗效果及不良反应发生率。结果:治疗后,两组患者LVESD、LVEDD、IMT水平下降,LVEF、6MWT水平升高,观察组LVESD、LVEDD、IMT水平低于对照组,LVEF、6MWT水平高于对照组,差异有统计学意义(P<0.05);治疗后,两组患者MMP-9、Hcy、PTX-3、Visfatin水平均下降,观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:缺血性心脏病患者开展可可碱注射液治疗效果显著,可有效改善患者心肌缺血情况,优化血液流变学指标,降低不良反应发生率,促使病情进展得到控制,促使患者及早恢复健康,安全性较高。Objective:To explore the clinical efficacy of theobromine injection treatment in patients with ischemic heart disease.Methods:A total of 74 patients with ischemic heart disease who were admitted to the First Department of Internal Medicine,Dongguan Hengli Hospital from January 2021 to July 2022 were selected as the observation objects.They were divided into control group and observation group by blind lottery,with 37 cases in each group.The control group was given routine treatment,and the observation group was treated with theobromine injection on the basis of the control group.The left ventricular endsystolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),carotid intima-media thickness(IMT),6 min walk test(6MWT),matrix metalloproteinase 9(MMP-9),homocysteine(Hcy),pentraxin 3(PTX-3),Visfatin,treatment effect and incidence of adverse reactions in two groups were observed.Results:After treatment,the levels of LVESD,LVEDD and IMT decreased in the two groups,while the levels of LVEF and 6MWT increased,the levels of LVESD,LVEDD and IMT in the observation group were lower than those in the control group,and the levels of LVEF and 6MWT were higher than those in the control group,with statistically significant differences(P<0.05).After treatment,the levels of MMP-9,Hcy,PTX-3 and Visfatin decreased in the two groups,and the levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Theobromine injection is significantly effective in the treatment of patients with ischemic heart disease,it can effectively improve the myocardial ischemia of patients,optimize hemorheological in

关 键 词：缺血性心脏病 可可碱注射液 心功能 不良反应 

分 类 号：R54[医药卫生—心血管疾病]