不同剂量昂丹司琼对无痛人流术孕妇的麻醉、苏醒效果及术后呕吐的影响  

Effect of Different Doses of Ondansetron on Anesthesia and Postoperative Vomiting in Pregnant Women Undergoing Painless Induced Abortion

作　　者：张竹青 孟雅静 ZHANG Zhu-qing;MENG Ya-jing(Department of Anesthesia,Shaanxi People's Hospital,Xi'an Shaanxi 710068)

机构地区：[1]陕西省人民医院麻醉科,陕西西安710068 [2]陕西省宝鸡市妇幼保健院,陕西宝鸡721000

出　　处：《医学临床研究》2022年第10期1528-1530,1534,共4页Journal of Clinical Research

摘　　要：【目的】观察不同剂量昂丹司琼对无痛人工流产手术(人流术)孕妇的麻醉、苏醒效果及术后呕吐的影响。【方法】在两院接受无痛人流术治疗的192例孕妇,根据用药情况将其划分为对照组、低量组、中量组、高量组每组48例。各组均采用地佐辛复合丙泊酚麻醉,其中对照组不予止吐药物,低量组于麻醉前给予2 mg昂丹司琼,中量组于麻醉前给予4 mg昂丹司琼,高量组于麻醉前给予8 mg昂丹司琼。比较各组孕妇术中指标、术后恶心、呕吐程度与苏醒质量,术后随访24 h统计各组额外止吐药物的应用情况。【结果】四组孕妇手术时间、麻醉时间、术中平均心率、平均动脉压(MAP)相比较,差异均无统计学意义(P>0.05)。对照组恶心、呕吐发生率为43.75%(21/48),低量组为20.83%(10/48),中量组与高量组均为6.25%(3/48),低量组、中量组、高量组均低于对照组(P<0.05),中量组、高量组均低于低量组(P<0.05),中量组与高量组之间相比较,差异无统计学意义(P>0.05)。各组孕妇自主呼吸恢复时间、唤醒睁眼时间、指令握拳时间、苏醒期躁动程度评分相比较,差异均无统计学意义(P>0.05)。对照组额外止吐药物应用率为27.08%(13/48),低量组为10.42%(5/48),中量组为2.08%(1/48),高量组无额外止吐药物应用情况。低量组、中量组与高量组应用率相比较,差异均无统计学意义(P>0.05),对照组应用率分别高于低量组、中量组与高量组(P<0.05)。【结论】无痛人流术中应用地佐辛配合昂丹司琼能够有效降低术后恶心、呕吐的发生率并减轻其程度,且配伍用药安全,且4 mg昂丹司琼较2 mg效果理想,用量增加至8 mg时效果未见明显提升。【Objective】To observe the effects of different doses of ondansetron on the anesthesia,recovery and postoperative vomiting of pregnant women undergoing painless induced abortion.【Methods】A total of 192 pregnant women who received painless induced abortion in both hospitals were divided into control group,low dose group,medium dose group and high dose group according to the medication situation;Each group was anesthetized with diazosine combined with propofol.The control group was not given antiemetic drugs.The low dose group was given 2 mg ondansetron before anesthesia,the medium dose group was given 4 mg ondansetron before anesthesia,and the high dose group was given 8mg ondansetron before anesthesia;The intraoperative indexes,postoperative nausea and vomiting degree and recovery quality of the pregnant women in each group were compared,and the use of additional antiemetic drugs in each group was counted after 24 h follow-up.【Results】There was no significant difference in operation time,anesthesia time,mean heart rate and mean arterial pressure(MAP)among the four groups(P>0.05).The incidence of nausea and vomiting was 43.75%(21/48)in the control group,20.83%(10/48)in the low dose group,6.25%(3/48)in the middle dose group and the high dose group.The low dose group,the middle dose group and the high dose group were lower than the control group(P<0.05),and the middle dose group and the high dose group were lower than the low dose group(P<0.05).There was no significant difference between the middle dose group and the high dose group(P>0.05).There was no significant difference in the recovery time of spontaneous respiration,the time of awakening eyes,the time of clenching fists under command,and the dryness degree score during the awakening period among the pregnant women in each group(P>0.05).The application rate of additional antiemetic drugs in the control group was 27.08%(13/48),10.42%(5/48)in the low dose group,2.08%(1/48)in the medium dose group,and no additional antiemetic drugs were used in the hig

关 键 词：昂丹司琼 流产 人工 麻醉 手术后恶心呕吐 

分 类 号：R719.7[医药卫生—妇产科学]