肺炎支原体合并EB病毒感染患儿血清IL-2、IL-12水平及其与患儿预后的相关性  

Serum IL-2 and IL-12 Levels in Children with Mycoplasma Pneumoniae and Epstein Barr Virus Infection and Their Correlation with Prognosis

作　　者：吴邹钰 孟发财[2] 张莉 李英 WU Zou-yu;MENG Fa-cai;ZHANG Li(Shaanxi Kangfu Hospital,Xi'an Shaanxi 710065)

机构地区：[1]陕西省康复医院,陕西西安710065 [2]陕西省人民医院,陕西西安710068 [3]西安市高新医院,陕西西安710014

出　　处：《医学临床研究》2022年第10期1546-1549,共4页Journal of Clinical Research

摘　　要：【目的】探讨肺炎支原体(MP)合并EB病毒感染患儿血清白细胞介素-2(IL-2)、白细胞介素-12(IL-12)水平及其与患儿预后的相关性。【方法】选取2019年5月至2020年5月陕西省人民医院收治的103例MP合并EB病毒感染的患儿(合并组)、103例单纯MP感染的患儿(MP组),选取同期进行体检的103例健康儿童(对照组)。根据合并组患儿预后情况将其分为不良预后组(n=32)和非不良预后组(n=71)。采用酶联免疫吸附(ELISA)法检测各组血清IL-2、IL-12水平,采用Logistic回归分析影响MP合并EB病毒感染患儿发生不良预后的因素,采用受试者工作特征(ROC)曲线分析血清IL-2、IL-12对MP合并EB病毒感染患儿不良预后的评估价值。【结果】合并组患儿血清IL-2、C反应蛋白(CRP)水平高于MP组、对照组,且MP组高于对照组(P<0.05);合并组患儿血清IL-12水平低于MP组、对照组,且MP组低于对照组(P<0.05)。不良预后组血清CRP、IL-2水平及发热时间均大于非不良预后组,血清IL-12水平低于非不良预后组(P<0.05)。Logistic回归分析结果显示:血清IL-2高表达是影响MP合并EB病毒感染患儿发生不良预后的独立危险因素,IL-12高表达是影响MP合并EB病毒感染患儿发生不良预后的保护因素(P<0.05)。ROC曲线分析显示:血清IL-2、IL-12及两者联合评估MP合并EB病毒感染患儿不良预后的曲线下面积分别为0.746、0.866、0.901,敏感度分别为64.5%、93.5%、83.9%,特异度为88.9%、79.2%、81.9%。【结论】MP合并EB病毒感染患儿血清IL-2水平升高、血清IL-12水平降低,且与预后密切相关,对患儿不良预后具有一定的预测价值,且二者联合预测价值更高。【Objective】To investigate the serum levels of interleukin-2(IL-2)and interleukin-12(IL-12)in children with mycoplasma pneumoniae(MP)and EB virus infection and their correlation with the prognosis of the children.【Methods】From May 2019 to May 2020,103 children with MP and EB virus infection(combined group),103 children with MP infection(MP group),and 103 healthy children(control group)who underwent physical examination at the same time were selected.According to the prognosis of children in the combined group,they were divided into poor prognosis group(n=32)and non poor prognosis group(n=71).The levels of serum IL-2 and IL-12 were detected by enzyme-linked immunosorbent assay(ELISA).Logistic regression analysis was used to analyze the factors affecting the poor prognosis of children with MP combined with EB virus infection.The ROC curve was used to analyze the evaluation value of serum IL-2 and IL-12 on the poor prognosis of children with MP combined with EB virus infection.【Results】The levels of serum IL-2 and CRP in the combined group were higher than those in MP group and control group,and those in MP group were higher than those in control group(P<0.05);The serum IL-12 level of children in the combined group was lower than that in MP group and control group,and MP group was lower than that in control group(P<0.05).Serum CRP,IL-2 levels and fever time in the poor prognosis group were higher than those in the non poor prognosis group,and serum IL-12 levels were lower than those in the non poor prognosis group(P<0.05).Logistic regression analysis showed that high expression of IL-2 in serum was an independent risk factor for poor prognosis of MP patients with EB virus infection,and high expression of IL-12 was a protective factor for poor prognosis of MP patients with EB virus infection(P<0.05).ROC curve analysis showed that the area under the curve of serum IL-2,IL-12 and their combination to evaluate the adverse prognosis of MP patients with EB virus infection were 0.746,0.866 and 0.901,respectively

关 键 词：肺炎 支原体 疱疹病毒4型 人 白细胞介素2/血液 白细胞介素12/血液 预后 

分 类 号：R725.631[医药卫生—儿科]