更昔洛韦抗病毒治疗巨细胞病毒肝炎患儿的临床疗效分析  

Clinical Efficacy of Ganciclovir in the Treatment of Cytomegalovirus Hepatitis in Children

作　　者：郭惠敏 张艳翔 宋建刚 GUO Hui-min;ZHANG Yan-xiang;SONG Jian-gang(Department of Pediatrics Baota District People's Hospital,Yan'an Shaanxi 716000)

机构地区：[1]延安市宝塔区人民医院儿科,陕西延安716000

出　　处：《医学临床研究》2022年第10期1560-1562,共3页Journal of Clinical Research

摘　　要：【目的】探讨更昔洛韦抗病毒治疗巨细胞病毒(CMV)肝炎患儿的临床疗效。【方法】回顾性分析2019年3月至2021年3月本院收治的88例巨细胞病毒肝炎患儿的临床资料,根据抗病毒治疗药物的不同将其分为观察组和对照组,每组44例。对照组患儿给予还原型谷胱甘肽治疗,观察组在对照组的基础上另给予更昔洛韦治疗。比较两组患儿黄疸消退时间、肝脏回缩时间、脾脏回缩时间,治疗前后血清总胆红素(TBIL)、谷丙转氨酶(ALT)、γ-谷氨酰转肽酶(GGT)水平,并比较两组患儿临床疗效及不良反应发生情况。【结果】观察组黄疸消退、肝脏回缩及脾脏回缩时间显著少于对照组,差异均有统计学意义(均P<0.05)。治疗后,两组患者血清TBIL、ALT、GGT水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组临床总有效率为93.18%(41/44),高于对照组的77.27%(34/44),差异有统计学意义(χ^(2)=4.423,P=0.036)。两组不良反应发生率比较,差异无统计学意义(χ^(2)=1.048,P=0.310)。【结论】更昔洛韦抗病毒治疗巨细胞病毒肝炎患儿能够缩短临床症状消失时间,促进肝功能恢复,且安全可靠。【Objective】To investigate the clinical efficacy of ganciclovir in the treatment of cytomegalovirus(CMV)hepatitis in children.【Methods】The clinical data of 88 children with cytomegalovirus hepatitis admitted to our hospital from March 2019 to March 2021 were analyzed retrospectively.They were divided into observation group and control group according to different antiviral drugs,with 44 cases in each group.The children in the control group were treated with reduced glutathione,and the children in the observation group were treated with ganciclovir on the basis of the control group.The jaundice regression time,liver retraction time,spleen retraction time,the level serum total bilirubin(TBIL),alanine aminotransferase(ALT),γ-glutamyltranspeptidase(GGT)before and after the therapy and the clinical efficacy and adverse reactions of the two groups were compared.【Results】The time of jaundice regression,liver retraction and spleen retraction in the observation group was significantly lower than that in the control group(P<0.05).After treatment,the levels of serum TBIL,ALT and GGT in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).The total clinical effective rate in the observation group was 93.18%(41/44),higher than that in the control group[77.27%(34/44)],with a statistically significant difference(χ^(2)=4.423,P=0.036).There was no significant difference in the incidence of adverse reactions between the two groups(χ^(2)=1.048,P=0.310).【Conclusion】Ganciclovir antiviral therapy can shorten the time of clinical symptom disappearance,promote the recovery of liver function,and it is safe and reliable.

关 键 词：肝炎 病毒性 人/药物疗法 巨细胞病毒感染 更昔洛韦/药理学 治疗结果 

分 类 号：R725.126[医药卫生—儿科]