抗-c抗体引起新生儿溶血病1例  

Hemolytic disease in a neonate caused by anti-c antibody

作　　者：胡燕[1] 徐颖 于红[1] Hu Yan;Xu Ying;Yu Hong(Department of Obstetrics,Zhongda Hospital Affiliated to Southeast University,Nanjing 210009,China;Department of Pediatrics,Zhongda Hospital Affiliated to Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学附属中大医院产科,南京210009 [2]东南大学附属中大医院儿科,南京210009

出　　处：《中华围产医学杂志》2022年第11期863-865,共3页Chinese Journal of Perinatal Medicine

摘　　要：报道1例抗-c抗体引起的新生儿溶血病患儿。患儿生后1 h出现面部和躯干部皮肤黄染并进行性加重,生后6 h血清总胆红素168.1μmol/L,血型O型RhDCcEe,直接抗人球蛋白试验、血清游离抗体试验、红细胞释放抗体试验均阳性;其母血型A型RhDCCee,血清中检出IgG型抗-c抗体,效价1∶4。给予患儿蓝光照射、免疫球蛋白及药物治疗后,痊愈出院。患儿生后1和3个月随访,体格发育及神经行为发育未见异常。We report a case of hemolytic disease of the newborn(HDN)caused by anti-c antibody.The baby boy presented progressive jaundice on his face and trunk one hour after birth.Total bilirubin of 168.1μmol/L was detected six hours after birth and positive results of direct antiglobulin test,serum free antibody test,and erythrocyte releasing antibody test were obtained.His blood type was O and RhDCcEe,while his mother was A and RhDCCee.IgG anti-c antibodies were identified in the maternal blood serum with the titer of 1∶4.After phototherapy,immunoglobulin infusion,and medication,the boy was recovered and discharged from the hospital.The boy was normal in both physical and neurobehavioral development at one and three months after discharge.

关 键 词：幼红细胞增多症 胎儿 RH-HR血型系统 免疫球蛋白G 婴儿 新生 

分 类 号：R722.18[医药卫生—儿科]