Electrochemiluminescence biosensing and bioimaging with nanomaterials as emitters  

作　　者：Yaqiang Feng Ningning Wang Huangxian Ju 

机构地区：[1]Research Center of Analytical Instrumentation,Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education,College of Chemistry and Materials Science,Northwest University,Xi’an 710127,China [2]State Key Laboratory of Analytical Chemistry for Life Science,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China [3]School of Pharmacy,Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment,Binzhou Medical University,Yantai 264003,China

出　　处：《Science China Chemistry》2022年第12期2417-2436,共20页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21804107,21890741,21827812);the State Key Laboratory of Analytical Chemistry for Life Science(SKLACLS1807);Taishan Scholars Construction Engineering(tsqn202103112);the support plan for youth entrepreneurship and technology of colleges and universities in Shandong Province(2021KJ052)。

摘　　要：The continuous emergence of novel luminophores has been leading the development of electrochemiluminescence(ECL)analysis since the ECL phenomenon of silicon nanoparticles was first reported in 2002.Nanomaterial-based luminophores termed as nanoemitters exhibit great application potential in ECL bioanalysis.In this review,we systematically summarize the research progress of various types of ECL nanoemitters,such as semiconductor quantum dots(QDs),carbon dots(CDs),polymer dots(Pdots),aggregation-induced emission nanoparticles(AIE dots),and other nanoemitters including luminophoredoped silica nanoparticles,metal-organic frameworks,covalent organic frameworks,and metal nanoclusters.We mainly emphasize the characteristic of these nanoemitters and their applications in ECL biosensing and bioimaging by using them as labels,and highlight some impressive cases in the last five years.Finally,we discuss current challenges in the field of ECL nanoemitters and point out their prospects.

关 键 词：ELECTROCHEMILUMINESCENCE nanoemitters BIOSENSING BIOIMAGING 

分 类 号：TB383.1[一般工业技术—材料科学与工程] O657.1[理学—分析化学]