HDV RNA检测的临床意义与方法  

Clinical significance and methods of hepatitis D virus RNA detection

作　　者：林妍雪 秦艳丽 张继明 LIN Yanxue;QIN Yanli;ZHANG Jiming(Department of Infectious Diseases,Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response,National Medical Center for Infectious Diseases,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院感染科,上海市传染病与生物安全应急响应重点实验室,国家传染病医学中心,上海200040

出　　处：《临床肝胆病杂志》2022年第12期2830-2835,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81871640,82172255)。

摘　　要：HDV感染的流行率和危害程度一直被低估,低筛查率和低诊断率或带来严重疾病负担。HDV RNA作为病毒复制的直接证据,对于丁型肝炎的诊断和管理具有重要意义。本文总结了HDV RNA检测的临床意义,并介绍了检测方法的进展,以期促进丁型肝炎的筛查和诊断。The prevalence and severity of hepatitis D virus(HDV)infection have always been underestimated,and the low screening and diagnosis rates may bring severe disease burden.HDV RNA,as the direct evidence of viral replication,is of great importance for the diagnosis and management of hepatitis D.This article summarizes the clinical significance of HDV RNA detection and introduces the advances in detection methods,in order to facilitate the screening and diagnosing of hepatitis D.

关 键 词：丁型肝炎 RNA 病毒 诊断 逆转录聚合酶链反应 

分 类 号：R512.64[医药卫生—内科学]