二苯丙氨酸二肽微纳米结构的可控组装及应用  

Controllable Assembly of Diphenylalanine Dipeptide Micro/Nano Structure Assemblies and Their Applications

作　　者：王克青 薛慧敏 秦晨晨 崔巍[1] Keqing Wang;Huimin Xue;Chenchen Qin;Wei Cui(Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China;National Museum of China,Beijing 100006,China)

机构地区：[1]中国科学院化学研究所,北京100190 [2]中国国家博物馆,北京100006

出　　处：《化学进展》2022年第9期1882-1895,共14页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21961142022,21872150,22072160)资助。

摘　　要：近年来,生物组装单元构筑微纳米结构的组装体在生物纳米技术等领域得到了广泛的研究。不同形貌的微纳米组装体可以通过生物分子的自组装这样快速、简便的方法获得。在众多肽基构筑基元中,二苯丙氨酸二肽及其衍生物作为一种生物活性的肽,具有生物兼容性好、容易化学修饰/生物功能化、制备简单等特点,是构筑微纳米结构材料时重要的生物基元之一。通过可控的方法组装,可以得到基于二苯丙氨酸及其衍生物的不同结构的组装体,他们在光学、机械工程、电化学传感检测等方面也具有广阔的应用前景。研究证明通过改变组装条件以及引入外源小分子等方法可以实现调控短肽的分子组装。本文综述了二苯丙氨酸二肽微纳米组装体的可控组装及他们在生物医学、生物传感、光电材料、光波导和催化等方面的应用。In recent years, the construction of micro/nano structure assemblies by biological assembly units has been extensively studied in the fields of bio-nanotechnology and other fields. Micro/nano structure assemblies with different morphologies can be obtained by a quick and simple method such as the self-assembly of biomolecules. Diphenylalanine dipeptide and its derivatives, as a biologically active peptide in many peptide-based building blocks, have good biocompatibility and characteristic for chemical modification, biological function and simple preparation. Micro/nano-materials with different structures based on diphenylalanine and its derivatives can be obtained by controllable assembled methods. They also have wide applications in optics, mechanical engineering, electrochemical sensing and detection areas, etc. Controlled assembly of short peptides and its derivatives can be achieved by changing the assembly conditions or introducing of exogenous small molecules. This review summaries and outlooks the controllable assembly of diphenylalanine dipeptide micro/nano structure assemblies and their applications in biomedicine, biosensor, optoelectronic materials, optical waveguides and catalysis.

关 键 词：分子组装 二苯丙氨酸二肽 生物医学 生物传感 光电材料 

分 类 号：O629[理学—有机化学]