经尿道膀胱肿瘤电切术联合靶向治疗对膀胱癌患者近远期生存率及p53基因表达的影响  

Effect of transurethral resection of bladder tumor combined with targeted therapy on short-term and long-term survival rate and p53 gene expression in patients with bladder cancer

作　　者：霍旺盛[1] 雷婷婷 HUO Wangsheng;LEI Tingting(Department of Urology,13th Division Red Star Hospital of the Xinjiang Production and Construction Corps,Xinjiang,Hami 839000,China;Department of Pharmacy,Hami Central Hospital,Xinjiang,Hami 839000,China)

机构地区：[1]新疆生产建设兵团第十三师红星医院泌尿外科,新疆哈密839000 [2]新疆维吾尔自治区哈密市中心医院药剂科,新疆哈密839000

出　　处：《中国医药科学》2022年第22期155-159,共5页China Medicine And Pharmacy

摘　　要：目的探讨尿道膀胱肿瘤电切术联合靶向治疗对膀胱癌患者近远期生存率及p53基因表达的影响。方法选取新疆生产建设兵团第十三师红星医院2015年12月至2016年12月共收治的60例膀胱癌患者为研究对象,依据随机数表法分为观察组(n=30)与对照组(n=30),对照组患者应用经尿道膀胱肿瘤电切术,观察组在对照组患者治疗基础上联合曲妥珠单抗进行靶向治疗。比较两组患者的近远期生存率、局部复发率、治疗前后p53基因表达情况、不良反应发生及生活质量情况。结果两组患者1年生存率比较,差异无统计学意义(P>0.05),观察组患者2、3、5年生存率明显高于对照组,差异有统计学意义(P<0.05)。两组患者1年局部复发率比较,差异无统计学意义(P>0.05),观察组患者2、3、5年局部复发率明显低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前p53基因阳性表达人数和阴性表达人数比较,差异无统计学意义(P>0.05),治疗后阳性表达人数减少,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组患者不良反应总发生率为43.33%,对照组为36.67%,两组比较差异无统计学意义(P>0.05)。治疗前,两组患者精神健康、情感职能、社会功能、活力、总体健康、生理职能、生理功能各项评分比较,差异无统计学意义(P>0.05),治疗后,两组患者各项评分显著升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论对膀胱癌患者进行经尿道膀胱肿瘤电切术基础上联合靶向治疗效果显著,能够提升患者近远期生存率,降低局部复发率,调节p53基因表达,安全性好,并且能够促进患者生活质量提升,值得临床应用推广。Objective To investigate the effect of transurethral resection of bladder tumor combined with targeted therapy on short-term and long-term survival rate and p53 gene expression in patients with bladder cancer.Methods A total of 60 patients with bladder cancer admitted to the 13th Division Red Star Hospital of the Xinjiang Production and Construction Corps from December 2015 to December 2016 were selected as the research subjects.They were divided into the observation group(n=30)and the control group(n=30)using the random number table,and patients in the control group were treated with transurethral resection of bladder tumors,while patients in the observation group were treated with trastuzumab targeted therapy on this basis.The short-term and long-term survival rate,local recurrence rate,p53 gene expression before and after treatment,adverse reactions and quality of life were compared between the two groups.Results There was no statistically significant difference in the 1-year survival rate between the two groups(P>0.05).The 2-year,3-year and 5-year survival rates of patients in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).There was no significant difference in 1-year local recurrence rate between the two groups(P>0.05).The 2-year,3-year and 5-year local recurrence rate in the observation group were lower than that in the control group,with statistically significant differences(P<0.05).There was no significant difference in the number of positive and negative p53 gene expression between the two groups before treatment(P>0.05).The number of positive p53 gene expression decreased after treatment,and the number in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).The total incidence of adverse reactions in the observation group was 43.33%,while that in the control group was 36.67%.There was no significant difference between the two groups(P>0.05).Before treatment,there was no stati

关 键 词：膀胱癌 靶向治疗 经尿道膀胱肿瘤电切术 P53基因表达 近远期生存率 

分 类 号：R737.14[医药卫生—肿瘤]