羟苯磺酸钙联合基础治疗方案对T2DN患者微循环的影响  

Effect of calcium dobesilate combined with basic treatment regimen on microcirculation in patients with T2DN

作　　者：夏彩霞[1] 姜晓文[1] 房京州 段冬梅 蔡明镜 杨志霞[1] 张宏颖[1] XIA Caixia;JIANG Xiaowen;FANG Jingzhou;DUAN Dongmei;CAI Mingjing;YANG Zhixia;ZHANG Hongying(Department of Endocrinology,Langfang Municipal People′s Hospital,Langfang,Hebei 065000,China)

机构地区：[1]河北省廊坊市人民医院内分泌科,河北廊坊065000

出　　处：《国际检验医学杂志》2022年第24期2991-2995,共5页International Journal of Laboratory Medicine

基　　金：河北省廊坊市科学技术研究与发展计划项目(2020013110)。

摘　　要：目的探讨羟苯磺酸钙联合基础治疗方案对2型糖尿病肾病(T2DN)患者的影响。方法选取2020年3月至2021年9月该院收治的T2DN患者128例作为研究对象,采用区组随机分组法分为观察组、对照组,每组64例。对照组给予基础治疗方案,观察组在对照组基础上联合羟苯磺酸钙治疗。比较两组疗效,治疗前后肾功能指标[β_(2)-微球蛋白(β_(2)-MG)、微蛋白尿(mALB)、血肌酐(Scr)]、炎症反应指标[白细胞介素(IL)-6、IL-18、肿瘤坏死因子-α(TNF-α)]、氧化应激指标[超氧化物歧化酶(SOD)、晚期糖基化终末产物(AGE)、丙二醛(MDA)]、微血管病变指标[腓骨蛋白-1(Fibulin-1)、生长分化因子-15(GDF-15)]水平及不良反应。结果观察组总有效率为93.75%(60/64),高于对照组的81.25%(52/64),差异有统计学意义(P<0.05);治疗后两组β_(2)-MG、mALB、Scr、IL-6、IL-18、TNF-α、AGE、MDA、Fibulin-1、GDF-15水平均低于治疗前(P<0.05),SOD水平高于治疗前(P<0.05);治疗后观察组β_(2)-MG、mALB、Scr、IL-6、IL-18、TNF-α、AGE、MDA、Fibulin-1、GDF-15水平均低于对照组(P<0.05),SOD水平高于对照组(P<0.05);观察组不良反应发生率为10.94%(7/64),与对照组的7.81%(5/64)相比,差异无统计学意义(P>0.05)。结论羟苯磺酸钙联合基础治疗方案治疗T2DN患者具有较好效果,可改善肾功能,抑制炎症反应,纠正氧化应激损伤,缓解微血管病变,安全、可靠。Objective To explore the effect of calcium dobesilate combined with basic therapeutic regimen on the patients with type 2 diabetic nephropathy(T2DN).Methods A total of 128 patients with T2DN in this hospital from March 2020 to September 2021 were selected as the study subjects and divided into the observation group and control group by adopting the block randomization method,64 cases in each group.The control group was given the basic treatment regimen,and the observation group was combined with calcium dobesilate on the basis of the control group.The efficacy,renal function indexes[β_(2)-microglobulin(β_(2)-MG),microalbuminuria(mALB),serum creatinine(Scr)],and inflammatory response indexes[interleukin(IL)-6,IL-18,tumor necrosis factor-α(TNF-α)],oxidative stress indicators[superoxide dismutase(SOD),advanced glycation end products(AGE),malondialdehyde(MDA)],microangiopathy indicators[Fibulin-1,growth differentiation factor-15(GDF-15)]before and after treatment,and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 93.75%(60/64),which was higher than 81.25%(52/64)in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels ofβ_(2)-MG,mALB,Scr,IL-6,IL-18,TNF-α,AGE,MDA,Fibulin-1 and GDF-15 in the two groups were lower than those before treatment(P<0.05),and the SOD level was higher than that before treatment(P<0.05).After treatment,the levels ofβ_(2)-MG,mALB,Scr,IL-6,IL-18,TNF-α,AGE,MDA,Fibulin-1 and GDF-15 in the observation group were lower than those in the control group(P<0.05),and the SOD level was higher than that in the control group(P<0.05).The incidence rate of adverse reactions in the observation group was 10.94%(7/64),which in the control group was 7.81%(5/64),and the difference was not statistically significant(P>0.05).Conclusion Calcium dobesilate combined with the basic therapeutic regimen has a good effect in the treatment of T2DN patients,can improve the renal function,inhibit the infl

关 键 词：2型糖尿病肾病 羟苯磺酸钙 微血管病变 肾功能 氧化应激 炎症反应 

分 类 号：R587.2[医药卫生—内分泌]